Flashcards
sedative-Hypnotics,Axiolytic,Anticonvulsants
Cards in this deck (37)
- 1Psycosis is due totoo much DA
- 2Antagonists do what?they block
- 3MAO is what?an enzyme that clears
- 4What do MAOIs doincrease DA, treat depression and relives muscle tension
- 5What do Hypnotics domake you sleep,
- 6Sedation and increasing dosesedation, hypnosis,anesthesia , coma
- 7Alcohol is processed byCYP enzymes in the liver
- 8How is alcohol processed?2 steps with 2 enzymes: Alc.dehydrogenase, and aldehyde dehydrogenase
- 9process that Alc is processedEthanol->enzyme: alc. Dehydrogenase->Acetaldehyde->Aldehyde dehydrogenase(mitichondria) ->acetate
- 10Men have more:Alc. dehdrogenase
- 11Asians lackaldehyde dehydrogenase
- 122 routes for metabolism of alcohalenzyme and alc. dehydrogenase and enzyme and cytochrom p540E1
- 13What does alcohol domesses with ion channels, interacts with DA pathways,activates GABA receptors,
- 14Activating GABA receptors does what?since it is inhibitory, it inhibits itself, so there is moreDA in nucleous accumbus( addicitive state)
- 15OPAMImutation increased release of DA,
- 16The process of ALc.VTA to NAccubus to the pre frontal cortex
- 17Wernicke Korsakoff Syndromeloss of muscle coordination and loss of learning and memory
- 18Fetal Alcohol- syndrommost comman, short nose, thin lip, low nasal bridge, small head, small eye opening
- 19Examples of treatments for Alcoholicslook at people that dont make the enzyme Aldehyde dehydrogenese, make a drug that in hibits such enzyeme
- 20Antabuse :inhibits aldehyde dehydrogense, people still abuse
- 21Axiolytics do what? and types?treat anxiety disorders: Pannic disorder, agoraphobia, benralized anxiety, PTSD, OCD
- 22What is used to tes anxilyticsElevated plus maze
- 23Desentization of GABA A leads tothe extinction of symptoms
- 24Allosentric modulatormake their own binding site: like Benzodiazepine
- 25GABA receptors make the inside more__Negative, parasympathetic inhibits,
- 26How does the GABE receptor make the indide more negative?Chloride makes it more megative
- 27Nicotinic Acetylcholine receptors alos areGABA receptors
- 28Muscrine is anGABA agonist
- 29Acetylcholine belongs toPAra sympathetic
- 30Benzodiazepines areAnxiolytics
- 31How do Benzodiazepines work?They work by activating the GABA NT system
- 32Busirpone: Atypicalnot a sedative/hypnotic, acts as 5-HTIA and 5-HT2 receptors as an Agonist, problems with grapefruits
- 33SSRIs are used forperseverance
- 34What do Anticonvulsants doThey enhance GABA inhibition of neural excitation caused by activity of NMDA(glutamate) NA+ channels
- 35Anticonvulsants do what?stop excitation to stop siezures
- 36What is PicrotoxinGABA antagonist (Block), excitation lots of firing, since it is desensitized and leads to excitation symptoms: non sedative hypnotic
- 37Alc inhibitsGlutamate
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- college Bio 36 Flashcards on sedative-Hypnotics,Axiolytic,Anticonvulsants, created by maxytrejo1 on 25/11/2013.
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