Daptomycin

Question	Answer
Daptomycin is effective against ______________	Staphylococci (like MRSA, MSSA) Streptococci (like Strep A, D, and Strep viridans) Anaerobes!
T/F: Daptomycin's antimicrobial spectrum extends to aerobic and anaerobic gram positive bacteria.	True
What do we use Daptomycin for?	hospital acquired pneumonia :/// complicated skin infections
Is daptomycin time-dependent or concentration dependent?	Concentration Dependent!
What does daptomycin depend on?	Activity of daptomycin is affected by the CONCENTRATION of Ca 2+
ok so how does daptomycin kill bacteria	1. it's inserted into the lipid bilayer 2. it aggregates in the cell membrane 3. depolarizes that baby with its potassium efflux (this results in a loss of membrane potential --> inhibition of protein, DNA, & RNA --> nonfunctional cell) 4. cell dead
Side effects of daptomycin	injection site pain, irritation, inflammation headache, insomnia, fever, rash nausea, vomiting, diarrhea
daptomycin + HMG-CoA reductase inhibitors = ???????	increased risk for myopathy (muscle weakness)
T/F: dosage modification is NOT necessary for hemodialysis patients	FALSE
What effect on clearance does daptomycin have in obese patients?	clearance is DECREASED
1. PAE of daptomycin? 2. t 1/2 of daptomycin?	1. prolonged PAE = 5-10 hrs 2. t 1/2 = 8-9 hrs
where does daptomycin primarily get excreted into?	URINE

Resource summary

	Created by Zainab Hassoun over 8 years ago