538660
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 7 years ago
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Description
| Question | Answer |
| Diarrhea | Change in frequency/consistency of stools |
| Dysentry | Abdominal pain, stool with blood/mucus |
| E.Coli- Gram Staining | Gram -ve bacilli |
| Coliform | Bacteria used to indicate sanitary conditions of food/water |
| E.Coli- Movement | Has peritrichous flagella |
| E.Coli- Lactose Fermenation | Positive |
| E.Coli- Culture Media | Grow on McConkey Agar |
| E.Coli- Antigens (Somatic) | Somatic O- Not species specific & causes many cross reactions |
| E.Coli- Antigens (Flagellar) | Flagellar H (Species specific, fewer cross reactions |
| E.Coli- Strain Recognition | Done through strains H & O combination |
| Serotype | A serologically distinguishable strain, leading to a specific disease syndrome |
| E.Coli- Common Infections | Urinary Tract Infections, Diarrhea |
| Pathotype | Infraspecific pathogen classification based on its pathogenicity in specific hosts |
| E.Coli- ETEC | Enterotoxic E.Coli |
| E.Coli- ETEC (CFAs) | Colonisation Factor Antigens that allow bacteria to bind to intestinal epithelial cells |
| E.Coli- ETEC (ST) | Stable Toxin- released to stimulate cGMP production |
| E.Coli- ETEC (LT) | Labile Toxin- Released to increase cAMP production |
| E.Coli- ETEC (Effect of ST & LT) | Increase lumen electrolytes, leading to diarrhea |
| E.Coli- ETEC (Infections) | Travelers diarrhea, varies from mild to severe |
| E.Coli- EPEC- | Enteropathogenic E.Coli |
| E.Coli- EPEC (Initial Attachment) | Uses bundle forming pili |
| E.Coli- EPEC (Intimate Attachment) | Done through a Type 3 Secretory System |
| E.Coli- EPEC (LEE) | Locus Enteric Effacement- pathogenicity island containing a needle like structure that injects host cell wall with Tir protein |
| E.Coli- EPEC (Tir Protein) | Remains in host cell wall and allows E.Coli to bind using Intimin on bacterial cell wall |
| E.Coli- EPEC (Effect on Cell) | Binding creates lesions that destroy the microvilli |
| E.Coli- EPEC (Infections) | Diarrhea in children under 2 |
| E. Coli- EHEC/STEC/VTEC | 3 Names, 1 Strain of E.Coli |
| E.Coli- EHEC | Enterohaemorrhagic E.Coli (due to bloody diarrhea) |
| E.Coli- STEC | Shiga Toxin Producing E. Coli- this strain produces Shiga toxin |
| E.Coli- VTEC | Veryocytoxin Producing E.Coli |
| E.Coli- EHEC/STEC/VTEC (Infections) | Haemorrhagic colitis (blood in feces) and is linked to Serious Haemolytic Uremic Syndrome |
| E.Coli- EHEC/STEC/VTEC (Reservoir) | Cattle |
| E.Coli- EHEC/STEC/VTEC (Sources) | Contaminated meat/vegetables |
| E.Coli- EHEC/STEC/VTEC (Binding) | Binds through pathogenicity islands like EPEC strain |
| E.Coli- EHEC/STEC/VTEC (Stx Phage) | Encodes the Shiga toxin |
| E.Coli- EHEC/STEC/VTEC (Shiga Secretion) | Can't happen- no secretory system- so toxin is released by cell lysis (hence no antibiotics on infection) |
| E.Coli- EHEC/STEC/VTEC (Receptor GB3) | Target of Shiga toxin on Pantch cells (intestine) or kidney epithelial cells |
| E.Coli- EHEC/STEC/VTEC (Effect of Shiga Toxin) | Prevents protein synthesis- leading to RBC lysis and kidney damage |