E. Coli as a UTI

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Flashcards by gina_evans0312, updated more than 1 year ago
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Medical Microbiology (Urinary Tract Infections) Flashcards on E. Coli as a UTI, created by gina_evans0312 on 03/06/2014.

Resource summary

Question Answer
Host Defenses- Urine High osmolarity and urea concentration- antibacterial properties
Host Defenses-Sphincters They existed
Part of UTI That Isn't Sterile Distal urether
Environment- E.Coli Endogenous intestinal bacteria
E.Coli- Ascending Route of Infection Endogenous intestine E.Coli colonise the female urethra and ascend into the bladder
UPEC Uropathogenic E.Coli
UPEC- Adhesins Bind to UTI epithelial cell receptors
UPEC Adhesins- Type 1 Fibriae Bind to to mannosideases (abundant in bladder cell epithelium)
UPEC Adhesins- P. Fimbriae Bind to glycolipids (abundant in renal epithelium)
UPEC Adhesins- Adherence Adherence activates TLRs, leading to cytokine production...
TLR4 mutations Associated with ABU
EPEC- Immune Response (Chemokine Receptor CXCR1) Associated with neutraphil movement across the epithelium
CXCR1 Deficiency Associated with severe pyelenephritis
EPEC Virulence Factors- Siderophoes Increase possible metabolites i.e. Aerobactins to acquire iron
EPEC Virulence Factors- Toxins I.e. Haemolytics
EPEC Virulence Factors- Capsule Prevents phagocytosis
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