E. Coli as a UTI

Question	Answer
Host Defenses- Urine	High osmolarity and urea concentration- antibacterial properties
Host Defenses-Sphincters	They existed
Part of UTI That Isn't Sterile	Distal urether
Environment- E.Coli	Endogenous intestinal bacteria
E.Coli- Ascending Route of Infection	Endogenous intestine E.Coli colonise the female urethra and ascend into the bladder
UPEC	Uropathogenic E.Coli
UPEC- Adhesins	Bind to UTI epithelial cell receptors
UPEC Adhesins- Type 1 Fibriae	Bind to to mannosideases (abundant in bladder cell epithelium)
UPEC Adhesins- P. Fimbriae	Bind to glycolipids (abundant in renal epithelium)
UPEC Adhesins- Adherence	Adherence activates TLRs, leading to cytokine production...
TLR4 mutations	Associated with ABU
EPEC- Immune Response (Chemokine Receptor CXCR1)	Associated with neutraphil movement across the epithelium
CXCR1 Deficiency	Associated with severe pyelenephritis
EPEC Virulence Factors- Siderophoes	Increase possible metabolites i.e. Aerobactins to acquire iron
EPEC Virulence Factors- Toxins	I.e. Haemolytics
EPEC Virulence Factors- Capsule	Prevents phagocytosis

Resource summary

	Created by gina_evans0312 about 10 years ago