Flashcards
Neural Induction 2
Cards in this deck (28)
- 1Define specification and commitment?Specification - some level of information directing a cell to its fate
Commit - how firmly that cell adheres to that fate - 2How are regional differences in induction achieved?induction of anterior most neural plate
- 3Differences in neural plate induced dependent on exact origin of .... ?Graft from first mesoderm, induces anterior head structures
If graft next piece to involute = trunk and tail - 4What did Hilde Mangold do?
- 5What are the key terms to describe a blastopore?
- 6What is the involuting marginal zone?The part of blastula that will ultimately reside in the inside of the embryo
- 7The first cells of the IMZ to involute into the centre of the blastopore produce what regional structure?anterior part of the animal - head
- 8The last cells of the IMZ to involute into the centre of the blastopore produce what regional structure?mesoderm of more posterior regions e.g. tail of tadpole
- 9What is the anterior head induced by (neural factors)?BMP inhibition and Wnt inhibition
- 10What happens when injected Wnt inhibitor (cerebrus) mRNA into ventral xenopus blastomeres?ectopic head structures (cement gland, olfactory placode)
- 11What does Wnt and BMP signalling do for the position dependent of neural induction?
- 12What is cerberus?Found in pharyngeal endomesoderm
Inhibitor of Wnt, BMP and Xwnt8 - 13What does Cerberus inhibit (antagonise)? Nodal related = ant signalling pathway
- 14What is the Wnt signalling pathway?
- 15What does BMP pathway look like?
- 16In normal Wnt signalling what does the protein bind to?Frizzled receptor
- 17What if FrzB?soluble form of frizzled
expressed in endomesoderm
locally inhibit Wnt signallling - 18How does Frzb inhibit Wnt signalling?
- 19What happens when Frzb is ectopic?Loss of posterior (trunk) structures
Development of anterior head structures only - 20What is dikkop?Inteferes with Wnt signalling anteriorly
- 21How does dikkop do this?
- 22What has an homology with chordin in drosophila?sog - short gastrulation
- 23Where is sog expressed?ventral side of fly embryo
- 24What happens when micro injection of sog into non-neurgenic region of the embryo?formation of ectopic neuronal tissue - just like chordin
- 25What TGF-beta like BMP protein is found in drosophila?decapentaplegic - dpp
- 26What is the interaction between dip and sog?directly antagonise each other
- 27In drosophila what determines cell fate on the dorsal-ventral axis?gradient of dorsal proteins e.g. dip and sog
- 28How does dip and dog work in drosophila?
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- Undergraduate Development of the Nervous System (Neural Induction) Flashcards on Neural Induction 2, created by Thomas Welford on 20/03/2014.
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