Flashcards
BIOCHEMISTRY PROTEINS
Cards in this deck (5)
- 1What does it mean that Haemoglobin is an allosteric protein?This means that the binding of oxygen to one of the subunits is affected by its interactions with the other subunits. In fact the binding of oxygen to one haemoglobin subunit induces conformational changes that are relayed to the other subunits, making them more able to bind oxygen by raising their affinity for this molecule. Thus the binding of oxygen to haemoglobin is said to be cooperative. In contrast the binding of oxygen to the single polypeptide chain of myoglobin is noncooperative. This is clearly shown by the oxygen dissociation curves of the two molecules.
- 2Molecular recognition depends oncomplementarity of shape
and charge distribution between
the ligand and the protein binding site - 3Protein flexibility inherent in many protein structures enable proteins to adapt to ligand on binding. And this is often essential for protein function.INDUCED FIT
- 4Where does the energy for driving binding events comes from?It is often provided by the
displacement of water molecules
from the ligand binding site - 5—
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- Flashcards on BIOCHEMISTRY PROTEINS , created by Margaret-Estefani Conde Paredes on 28/11/2016.
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- Margaret-Estefani Conde Paredes
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