756263
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Genome Type | ds DNA |
| Size | Small |
| Envelope | None |
| Location of Replication (Type of cell) | Differentiating Epithelium |
| No of Open Reading Frames | Several |
| Variation in ORF Expression | 8-10 vary in early/late stages of infection |
| ORF Variation | Differentiate according to different promoters/splicing |
| Use of Machinery | Uses cells own machinery |
| HPV16 Infection | Basal layer of cervix wall, which is differentiating |
| HPV16 Entry | Accesses via microabrasions |
| Proteins for Entry | Cell Surface Integrins & Haperine Sulphate Proteoglycans |
| Inside the Nucleus- Replication System | Replicates once per cell cycle along with the cell |
| Inside the Nucleus- Expression of Viral Proteins | Alter cell growth, causing a wart |
| Terminal Differentiation of the Host Cell | Causes viral particle production, which are then shed |
| Terminal Differentiation of the Host Cell (Growth) | Cell growth is abnormal, may progress to cancer, may not |
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