756377
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Requirements | Further genetic changes |
| HPV Integration | Randomly integrates into host genome and will no longer replicate |
| Aberrant Proteins | E6 & E7 |
| Role of E6 | Binds to p53 and marks it for degredation & upregulates telomerase |
| Role of E7 | Binds to pocket region of Rb gene and displaces its transcription factors |
| Aberrant Gene Expression & Continued Growth | Makes cancer much more likely |
| Levelling of E6/E7 Expression | Used to assess risk of cancer progression |
| Level E6/E7 - Low | Insufficient expression for genetic alterations to accumulate |
| Level E6/E7 - High | Greatest cancer risk |
| HPV & Anal Cancer | V. rare, and more common in women than men |
| Immunocompromised People | Most at risk for cancer |
| HPV & Cervical Cancer | 99.7% of c.c. species are HPV positive |
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