Polio

Description

Virology (RNA Viruses) Flashcards on Polio, created by gina_evans0312 on 14/04/2014.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 about 10 years ago
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Resource summary

Question Answer
Type of RNA +ve sense ss
+ve Sense DNA Use Same orientation of mRNA, so is used as such
Initial Symptoms Malaise, headaches, sore throat, vomiting
Prolonged Symptoms Paralysis (months to lifelong)
Incubation 7-14 days
Time for Emergence of Symptoms 1 month
Transmission Blood, sputum and feces
5' End of Genome VpG protein, followed by long untranslated region
3' End of Genome Poly A tail
Protein Formation Done by differential splicing
Genome Translation Whole genome is translated and read as one mRNA
Direction of Replication 5' to 3' to make +ve snse RNA (Replication Intermediate 1)
Replication Intermediate 1 Recognised by multiple polymerases at once to make new genomes
Role of Multiple Replicases Prevents ds RNA formation, which causes interferon response
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