LOS & Vaccine

Question	Answer
LOS	Lipo-Oligosaccharides
LOS Release	Usually during cell death, but can be released in vesicles
LOS & TLR4	LOS stimulates TLR4 on macrophage surface leading to the release of cytokines
LOS & Shock	Release of cytokines by TLR4 leads to shock like symptoms in the body
LOS & Rash	Release of cytokines uses up compliment factors leading to bleeding under the skin and distinctive rash
Vaccine- Components	Capsular polysaccharides on a carrier protein
Vaccine- Use	Igs and memory cells are produced against capsular proteins, conveying protection and reducing colonisation, preventing spread to others
Vaccine- Response Time	A few weeks
Vaccine- Variations	Stains vary (6 of 13 causes menin.) so vaccine focuses on Men. C
Vaccine- Men. B	Common in Europe but no vaccine

Resource summary

	Created by gina_evans0312 about 10 years ago