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Diagnostic algorithm

Neutropenic, HSCT or SOT

Diabetic

Trauma

Trauma

Asia, specifically China

and India

Asia, specifically India

Chest CT

Cranial CT

Cranial MRI

Chest CT

Imaging of injured

regions as appropriate

Ultrasound/abdominal CT

Ultrasound/abdominal CT

Staging

Sampling

Biopsy

Serology

Galactomannan, 1,3-beta-D-glucan

Direct microscopy using

flourescent brightener

and histopathology with

special stains (eg PAS and

GMS)

Culture

Routine media at 30°C

and 37°C

Molecular identification

Preferably semi-nested

qPCR, HRM, Multiplex

Target: 18s, ITS, 28s or

rDNA

Susceptibility testing