Celiac Disease

Signs & Symptoms
1. Anemia
2. Bloating
3. Fatigue
4. Diarrhea
5. Flatulence
6. Edema
7. Easy bruising & bleeding
Risk factors
1. Family history
2. Autoimmune disorder
3. Genetic disorders
4. Age & Gender
5. Ethnicity
Causes
1. Intolerance to gluten
2. HLA-DQ2 & DQ8
  1. Increases risk of disease, but not every person who has this gene will necessarily develop it
    1. First-degree relatives have a 40% chance, so they have to do genetic testing
Pathogenesis & Immunology
Complications
1. Lactose intolerance
2. Malnutrition
3. Bone loss
  1. Osteoporosis
    1. Bone density test
4. Infertility
5. Cancer
6. Psychological
  1. Anxiety
  2. Depression
Investigations
1. Serology
2. IgA TTG
3. Physical examination
  1. Protuberant and Tympanic abdomen
  2. Weight loss
  3. Orthostatic hypotension
  4. Ascites
  5. Cheilosis and glossitis
  6. Dermatitis herpetiformis
  7. Ecchymoses
  8. Evidence of peripheral neuropathy
  9. Chvostek sign
4. Stool exam
5. Hematologic tests
6. Electrolytes
7. Oral tolerance test
8. CT enteroclysis
9. Endoscopy & biopsy
Management
1. Gluten-free diet

Resource summary

	Created by wedad attar about 6 years ago