1614408
Description
Mind Map by Maxmo Baztastico, updated more than 1 year ago
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Created by Maxmo Baztastico
over 10 years ago
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Protein
misfolding
diseases
- Proteopathy
- Neurodegenerative
diseases
- Huntington's
- ALS
- Creutzfeld-Jakob disease
- Parkinson's
- Huntington's
- Biological prevention
- PQC
- Chaperones
- " Interestingly, the existence of chaperones implies that some proteins
have inherently unstable conformations that can "flip" from a
functional minimal-energy state to a state that is nonfunctional or even
toxic." Nature
- " Interestingly, the existence of chaperones implies that some proteins
have inherently unstable conformations that can "flip" from a
functional minimal-energy state to a state that is nonfunctional or even
toxic." Nature
- PQC
- General susceptability
- Pathophysiology
- Amyloids
- "Misfolded proteins (also called toxic conformations) are typically
insoluble, and they tend to form long linear or fibrillar aggregates
known as amyloid deposits. " Nature
- "...the transition from alpha helix to beta sheet is characteristic of
amyloid deposits. The abnormal conformational transition from alpha
helix to beta sheet exposes hydrophobic amino acid residues and
promotes protein aggregation." Nature
- "...the transition from alpha helix to beta sheet is characteristic of
amyloid deposits. The abnormal conformational transition from alpha
helix to beta sheet exposes hydrophobic amino acid residues and
promotes protein aggregation." Nature
- "Misfolded proteins (also called toxic conformations) are typically
insoluble, and they tend to form long linear or fibrillar aggregates
known as amyloid deposits. " Nature
- Tau proteins
- Energy funnel
- Multiple low-energy
folding states
- One functional
- One functional
- Multiple low-energy
folding states
- "As we age... ...the delicate balance of the synthesis, folding, and
degradation of proteins is perturbed, resulting in the production
and accumulation of misfolded proteins that form aggregates"
Nature
- Amyloids
- Sources
- http://www.ncbi.nlm.nih.gov/pubmed/16722804
- http://www.ncbi.nlm.nih.gov/pubmed/22647474
- Nature : http://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929
- Pics
- Misfolding prot. metabolism
- http://www.nature.com/scitable/content/ne0000/ne0000/ne0000/ne0000/14463077/f3_dobson_nature02261-f2.2.jpg
- http://www.nature.com/scitable/content/ne0000/ne0000/ne0000/ne0000/14463077/f3_dobson_nature02261-f2.2.jpg
- Misfolding prot. metabolism
- http://www.neurobiologyofaging.org/article/S0197-4580(00)00160-3/abstract
- IFLSCIENCE:
http://www.iflscience.com/brain/alzheimer-s-memory-disorder-identified
- http://www.ncbi.nlm.nih.gov/pubmed/16722804
- Prions:
Transmissible
spongiform
encephalopathies
- BSE
- kuru
- BSE
- Neurodegenerative
diseases
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