Antiphospholipid syndrome

Laura Smitherman
Mind Map by Laura Smitherman, updated more than 1 year ago
Laura Smitherman
Created by Laura Smitherman about 5 years ago
6
1

Description

Mind Map on Antiphospholipid syndrome, created by Laura Smitherman on 02/16/2015.

Resource summary

Antiphospholipid syndrome
1 Cause
1.1 autoimmune
1.1.1 ?antiphospholipid antibodies
1.1.1.1 lupus anticoagulant
1.1.1.2 anti-cardiolipin
1.1.1.3 anti-β2-glycoprotein-I
1.1.2 complement and platelet activation
1.2 genetic
1.3 unknown
2 presentation
2.1 hypercoagulable state
2.1.1 venous
2.1.1.1 DVT
2.1.1.2 PE
2.1.2 arterial
2.1.2.1 stroke
2.2 pregnancy complications
2.2.1 stillbirth
2.2.2 miscarriage
2.2.3 preterm delivery
2.2.4 severe pre-eclampsia
2.3 Livedo reticularis
2.4 haemolytic anaemia
2.5 thrombocytopenia
3 Types
3.1 Primary
3.1.1 HLA-DR7
3.2 Secondary
3.2.1 risk factors
3.2.1.1 associated with other autoimmune diseases e.g. SLE, RA
3.2.1.2 HLA-B8, HLA-DR2, HLA-DR3
3.2.1.3 ethnicity
3.2.1.4 most common in young fertile women
4 Management
4.1 Lifestyle to reduce cardiovascular risks
4.2 Thrombosis risk
4.2.1 Acute
4.2.1.1 Heparin
4.2.2 Long term
4.2.2.1 Warfarin (INR 2-3) or antiplatelet
4.3 In pregnancy
4.3.1 LMWH + aspirin
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