2239527
Andrenergic Agonist Drugs
- Epinephrine
- Direct acting adrenergic agonist
that stimulates all a- and B-
adrenergic receptors
- a1
Effector
Organs
- Blood Vessels
- Constriction
- Constriction
- Pancreas
- Inhibition of insulin secretion
- Inhibition of insulin secretion
- Intestine and bladder
- Relaxation and Constriction of the
sphincters
- Relaxation and Constriction of the
sphincters
- Blood Vessels
- a1
Effector
Organs
- a2
Effector
Organs
- Postganglionic
- Inhibition of norepinephrine release
- Inhibition of norepinephrine release
- CNS
- Increase in potassium
conductance
- Increase in potassium
conductance
- Platelets
- Aggregation
- Aggregation
- Postganglionic
- B1
Effector
Organs
- Heart
- Increased heart rate,
increased contractility,
increased conduction
velocity
- Increased heart rate,
increased contractility,
increased conduction
velocity
- Fat Cell
- Lipolysis
- Lipolysis
- Heart
- B2
Effector
Organs
- Blood vessels
- Dilation
- Dilation
- Bronchioles
- Dilation
- Dilation
- Uterus
- Relaxation
- Relaxation
- Kidneys
- Renin Secretion
- Renin Secretion
- Liver
- Gluycogenesis, gluconeogenesis,
- Gluycogenesis, gluconeogenesis,
- Pancreas
- Insulin secretion
- Insulin secretion
- Blood vessels
- Cardiac stimulant that increases
contractibility and heart rate,
bronchospasm in asthma, COPD
- Intravenous, intramuscular, subcutaneous,
intraosseous, oral inhalation, endotracheal,
and topical
- Adverse effects include anxiety,
headache, tremors, pallor, sweating,
nausea, vomiting,hypertension,
tachycardia, cardiac arrhythmias,
cardiac ischemia, and intracranial
hemorrhage
- Intravenous, intramuscular, subcutaneous,
intraosseous, oral inhalation, endotracheal,
and topical
- Direct acting adrenergic agonist
that stimulates all a- and B-
adrenergic receptors
- Norepinephrine
- Vasopressor: The ability of a substance to
cause vasoconstriction of blood vessels and
resultant increases in blood pressure
- a1, a2, B1
receptors
- Intravenously
- Most commonly used to
restore blood pressure
- Adverse effects include: enhanced
plasma volume depletion, and
enhanced damage to the bowels,
kidney, and liver
- Vasopressor: The ability of a substance to
cause vasoconstriction of blood vessels and
resultant increases in blood pressure
- Ephedrine
- Adverse effects include: excessive CNS stimulation,
anxiety, restlessness, headache, blurred vision,
insomnia, seizures, palpatations, arrhythmias, pallor,
tachycardia, chest pain, and severe hypertension
- Precautions: Prolonged use may produce a
syndrome resembling an anxiety state.
Tolerance to ephedrine sulfate may develop,
but temporary discontinuance to the drug
restores its original effectiveness.
- a1, a2, B1 and B2
- Adverse effects include: excessive CNS stimulation,
anxiety, restlessness, headache, blurred vision,
insomnia, seizures, palpatations, arrhythmias, pallor,
tachycardia, chest pain, and severe hypertension
- Dopamine
- Indications: Treatment of
shock states, low cardiac
output syndromes, and
hypotension, and as an
adjunct to increase cardiac
output and blood pressure
during cardiopulmonary
resuscitation
- High Dose: The
agent will promote
vasoconstriction by
directly stimulating
a- adrenergic
recptors and by
causing the release
of norepinephrine
from sympathetic
nerve terminals
- Low Dose:At low and
moderate doses, dopamine
cause dopaminergic and
B1- adrenergic effects,
resulting in increased
renal and splanchnic blood
flow and increased cardiac
contractibility,
respectively.
- Adverse Effects:
Hypotension, hypertension,
ectopic beats, tachycardia,
palpitations,
vasoconstriction, angina,
dyspnea, and cardiac
conduction abnormalities
and widened ORS intervals
- Indications: Treatment of
shock states, low cardiac
output syndromes, and
hypotension, and as an
adjunct to increase cardiac
output and blood pressure
during cardiopulmonary
resuscitation
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