352479
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Mind Map by stephdos, updated more than 1 year ago
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Created by stephdos
over 10 years ago
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Copied by stephdos
over 10 years ago
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Gas Exchange and Transport_1
- Resting Oxy consumption=250mL min-1
- Produce 200mL min-1 of CO2
- Produce 200mL min-1 of CO2
- Direction of exchange of Oxy
- Lungs, 02 diffuse from alveoli to capillary blood
- Systemic cap beds, 02 from blood to cells via interstitial fluid
- C02 opp direction
- Lungs, 02 diffuse from alveoli to capillary blood
- Dalton's Law
- Total P= P1+P2+P3 etc ( total of all gases in same vol)
- Total P= P1+P2+P3 etc ( total of all gases in same vol)
- Alveolar Air
- Atmospheric air inhaled...
- saturated with water vapour
- mix with air with high CO2 in resp' dead space
- mix with air with high CO2 in resp' dead space
- saturated with water vapour
- Higher PCO2 + lower P02 than atmo air
- Atmospheric air inhaled...
- Rate of gas diffusion
- Directly proportional to
- conc grad across memb
- surf area of memb
- Permeabilty of memb to the gas
- conc grad across memb
- Inversely prop to
- thickness of memb
- thickness of memb
- Directly proportional to
- Henry's Law
- amount of gas that dissolves in a liq dep' on partial pressure of gas and its solubility
- O2 less soluble than CO2
- amount of gas that dissolves in a liq dep' on partial pressure of gas and its solubility
- 'Perfusion Limited'
- rate of g.exch dep' on rate of pulmonary blood flow
- rate of g.exch dep' on rate of pulmonary blood flow
- Haemoglobin
- protein in rbcs
- Bind to oxy- oxyhb
- reversible
- reversible
- Bind to oxy- oxyhb
- 4 subunits, 4 haem groups cont Fe2+
- each haem 1O2 so 1Hb transports 4O2
- Binding dep on PO2 in fluid
- O2 dissociation curve
- sigmoidal 'S'
- binding ability dep on no of o2 already bound
- bind 1 inc affinity for O2= Positive Cooperativity
- bind 1 inc affinity for O2= Positive Cooperativity
- RIGHT SHIFT: dec affinity
- LEFT: inc affinity
- FACTORS
- Inc temp = dec affinity
- dec pH= dec affinity BOHR EFFECT
- Carbamino effect. Hb +CO2 = HbCO2
- Lower aff for O2
- Lower aff for O2
- 2,3-BPG
- High levels decrease aff for O2
- OxyHb Inhibits enzyme that prod this
- High levels decrease aff for O2
- Inc temp = dec affinity
- sigmoidal 'S'
- O2 dissociation curve
- Binding dep on PO2 in fluid
- conc Hb in blood 150g L-1
- each haem 1O2 so 1Hb transports 4O2
- protein in rbcs
- CO2 TRANSPORT
- 3 ways
- bound to Hb
- Diss in plasma
- dissolved in form HCO3- ions
- bound to Hb
- dif into systemic caps
- dif into RBCS, converted to HCO3- + H+
- Prevent 'prod inhibition', HCO3- exch for Cl-
- In pulmonary caps, CO2 dif into alveolar gas, red PCO2 in blood
- Prevent 'prod inhibition', HCO3- exch for Cl-
- dif into RBCS, converted to HCO3- + H+
- binding O2 to Hb dec CO2 transp
- Haldane effect
- inc rate of CO2 elimination
- inc rate of CO2 elimination
- In systemic caps, low PO2 prom' binding CO2 to Hb
- Assists removal CO2 from tissues
- Assists removal CO2 from tissues
- Haldane effect
- 3 ways
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