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Lipid Raft

Description

[Plasma membran organisation]
ScoubidoOo
Mind Map by ScoubidoOo, updated more than 1 year ago
ScoubidoOo
Created by ScoubidoOo over 10 years ago
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Resource summary

Lipid Raft
  1. Fonctions
    1. Transduction of signal
      1. Rcp + L
        1. Recruitment of proteins
      2. Endocytosis (of receptors)
        1. CD44 + LR
          1. Ac. hyaluronic
            1. Internalisation (via Calveolin)
              1. Lysosome
                1. RCP degrated
        2. Cellular polarisation
          1. Apical MB : GPI proteins
            1. Basal MB : MB proteins
            2. Viral budding
              1. Hemagglutin
            3. Structure
              1. 35-40% in plasma MB
                1. Outer layer
                  1. Cytosolic face
                    1. Calveolin
                      1. Stabilisation of LR
                  2. Composition
                    1. Cholesterol
                      1. +++
                        1. MB rigidity
                        2. Glycoshingolipids
                          1. Shyngosine
                            1. Outer leaflet of the lipid bilayer
                              1. When @ cell surface
                                1. Intercellular communication
                                  1. Important role in cell adhesion mecanisms
                                  2. When associated with LR
                                    1. Signal transduction
                                      1. Receptor for pathogens
                                        1. Addressing proteins
                                      2. Proteins
                                        1. GPI-anchored proteins
                                          1. Associated to the MB
                                            1. Biosynthesis of GPI-proteins
                                              1. PICTURE
                                            2. MB proteins
                                              1. Extracellular domain
                                                1. EGF receptor
                                                  1. Area rich in cystein
                                                  2. Transmembrane domain
                                                    1. Ex : for virus enveloppe
                                                      1. Hemagglutin
                                                        1. HA1 : attachement viral particule
                                                          1. HA2 : release of the virus' contents
                                                      2. Intracellular Domain
                                                        1. For LR adressing
                                                    2. Microdomaine formation via linking between
                                                      1. Cholesterol
                                                        1. Glycosphingolipids
                                                        2. Detergent insoluble
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