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424697
Lipid Raft
Description
[Plasma membran organisation]
Mind Map by
ScoubidoOo
, updated more than 1 year ago
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Created by
ScoubidoOo
over 11 years ago
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Resource summary
Lipid Raft
Fonctions
Transduction of signal
Rcp + L
Recruitment of proteins
Endocytosis (of receptors)
CD44 + LR
Ac. hyaluronic
Internalisation (via Calveolin)
Lysosome
RCP degrated
Cellular polarisation
Apical MB : GPI proteins
Basal MB : MB proteins
Viral budding
Hemagglutin
Structure
35-40% in plasma MB
Outer layer
Cytosolic face
Calveolin
Stabilisation of LR
Composition
Cholesterol
+++
MB rigidity
Glycoshingolipids
Shyngosine
Outer leaflet of the lipid bilayer
When @ cell surface
Intercellular communication
Important role in cell adhesion mecanisms
When associated with LR
Signal transduction
Receptor for pathogens
Addressing proteins
Proteins
GPI-anchored proteins
Associated to the MB
Biosynthesis of GPI-proteins
PICTURE
MB proteins
Extracellular domain
EGF receptor
Area rich in cystein
Transmembrane domain
Ex : for virus enveloppe
Hemagglutin
HA1 : attachement viral particule
HA2 : release of the virus' contents
Intracellular Domain
For LR adressing
Microdomaine formation via linking between
Cholesterol
Glycosphingolipids
Detergent insoluble
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