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Lipid Raft

Description

[Plasma membran organisation]

Mind Map by ScoubidoOo, updated more than 1 year ago

	Created by ScoubidoOo about 12 years ago

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Resource summary

Lipid Raft

Fonctions
1. Transduction of signal
  1. Rcp + L
    1. Recruitment of proteins
2. Endocytosis (of receptors)
  1. CD44 + LR
    1. Ac. hyaluronic
      1. Internalisation (via Calveolin)
        Lysosome
        RCP degrated
3. Cellular polarisation
  1. Apical MB : GPI proteins
  2. Basal MB : MB proteins
4. Viral budding
  1. Hemagglutin
Structure
1. 35-40% in plasma MB
2. Outer layer
3. Cytosolic face
  1. Calveolin
    1. Stabilisation of LR
Composition
1. Cholesterol
  1. +++
  2. MB rigidity
2. Glycoshingolipids
  1. Shyngosine
  2. Outer leaflet of the lipid bilayer
  3. When @ cell surface
    1. Intercellular communication
    2. Important role in cell adhesion mecanisms
  4. When associated with LR
    1. Signal transduction
    2. Receptor for pathogens
    3. Addressing proteins
3. Proteins
  1. GPI-anchored proteins
    1. Associated to the MB
    2. Biosynthesis of GPI-proteins
      1. PICTURE
  2. MB proteins
    1. Extracellular domain
      1. EGF receptor
      2. Area rich in cystein
    2. Transmembrane domain
      1. Ex : for virus enveloppe
        Hemagglutin
        HA1 : attachement viral particule
        HA2 : release of the virus' contents
    3. Intracellular Domain
    4. For LR adressing
Microdomaine formation via linking between
1. Cholesterol
2. Glycosphingolipids
Detergent insoluble

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