null
US
Sign In
Sign Up for Free
Sign Up
We have detected that Javascript is not enabled in your browser. The dynamic nature of our site means that Javascript must be enabled to function properly. Please read our
terms and conditions
for more information.
Next up
Copy and Edit
You need to log in to complete this action!
Register for Free
472548
hyperlipidaemia
Description
Paediatrics (Endocrine & metabolic) Mind Map on hyperlipidaemia, created by v.djabatey on 09/01/2014.
No tags specified
endocrine & metabolic
paediatrics
paediatrics
endocrine & metabolic
Mind Map by
v.djabatey
, updated more than 1 year ago
More
Less
Created by
v.djabatey
over 10 years ago
27
0
0
Resource summary
hyperlipidaemia
a major risk factor for coronary heart disease
IDn & Rx during childhood may delay onset of CVD in later life
screen kids if at increased risk
parent or grandparent w/ hx of CHD before 55 years
fam hx of lipid disorder
if high serum cholesterol (i.e. >5.3 mmol/L) on random testing
measure triglyceride, LDL & HDL
secondary causes
obesity
hypothyroidism
diabetes mellitus
nephrotic syn
obstructive jaundice
familial hypercholesterolaemia
autosomal dominant
pathology
defect in LDL receptor
incidence
1 in 500
associations
premature coronary heart disease
occurs in 50% by 50 years in males and by 60 years in females
clinical features
xanthomata
skin
tendon
uncommon in childhood
Mx
drug therapy
age= 10 years or more
fam hx of premature CHD (< 55 yrs old)
evidence of tissue lipid deposition
xanthomata
bruits
non-lipid risk factors
eg. diabetes
bile acid sequestrants
moderately effective
compliance issues
statins (HMG-CoA reductase inhibitors)
effective
no -ve effects on growth, maturation or endocrine function
fenofibrate (fibrate)
well tolerated-kids & teens
homozygous genotype
very rare
very severe
xanthomata in childhood
cardiovascular disease in the 20s
refer to specialist centre
Mx
drug
response varies acc to gene mutation
liver transplant
Show full summary
Hide full summary
Want to create your own
Mind Maps
for
free
with GoConqr?
Learn more
.
Similar
Hypoglycaemia
v.djabatey
parathyroid disorders
v.djabatey
Hypothyroidism
v.djabatey
Adrenal cortical insufficiency
v.djabatey
Cushing's syndrome
v.djabatey
Inborn errors of metabolism
v.djabatey
Hyperthyroidism
v.djabatey
Newborn screening
v.djabatey
Child development
as0180.2010
infective endocarditis
v.djabatey
Bronchiolitis
v.djabatey
Browse Library