hiv classification and structure

hiv classification and structure

1. virus family

   • retroviridae
     • RNA genome replicates through DNA interned
   • so classes as a genus lentivirus
     • meaning slow

2. structure

   • diploid genome
     • homodimers of + sense single stranded RNA
       • 7-11 kb
   • circular particle: 50nm in diameter
   • widely distributed in vertebrates
   • cone shaped core

3. hiv 1 and 2

   • 1 is much more virulent

4. vision structure

   • 72 spikes on surface
     • glycoproteins p120 and gp 41
     • encoded by ENV
     • CD4 t cell receptor is on p120
   • capsid protein
     • forms a cone shaped capsid around ribonucleoprotein
     • p24
     • encoded by GAG
   • p17 matrix protein: lines inner surface of lipid envelope
   • p7 and p9
     • form a ribonucleoprotein couple with the ran genome
   • 50 molecules of reverse transcriptase as well as protease and integrate
     • bound to diploid +ss RNA
     • encoded by POL

5. HIV genome

   • 9 genes in total organised in complex way
   • GAG POL and ENV genes 1-3 are flanked by regulatory sequences known as long terminal repeats
     • so basically: theres is an LTR then the three genes in a line then an LTR
   • has an additional 6 accessory genes
     • rev, tat, nef wif vpr and vpu