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Aspergillosis

gabrielthan English

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Aspergillosis

  1. General Characteristics

    • Affect both healthy and immunocompromised
    • Etiological agents: Aspergillus spp.
      • A. fumigatus most common, ubiquitous
    • Transmission: inhalation of conidia
  2. Clin. issues and Dx

    • Invasive aspergillosis - Charac. by blood vessel thrombosis, infarction and airways blockage, widespread organ destruction
    • Aspergilloma: fungal balls within infected lungs and sinus cavities
    • Allergic bronchopulmonary aspergillosis (ABPA) - Allergic reaction => asthmatic condition
    • Lab dx: Isolation of A. fumigatus, small, fluffy white/green colonies, sporulation within 2 days
    • Serological test e.g. ELISA
  3. Treatment

    • Systemic AmB or itraconazole
    • Voriconazole & caspofungin (new drugs) refractory invasive aspergillosis
    • Surgery for some cases

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Mind Map on Aspergillosis, created by gabrielthan on 12/03/2014.
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