63787
Description
Mind Map by Mahmoud Jeilani, updated more than 1 year ago
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Created by Mahmoud Jeilani
about 11 years ago
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intravsation
- process in which a cancer cell enters the lumen of lymphatic or blood vessels.
- The first step in this process is specific adhesion to venular endothelial cells
- followed by adherence to proteins of the subendothelial basement membrane, such as laminin and types IV and V collagen
- The final step is the adhesion of the metastatic tumor cell to connective tissue elements such as fibronectin, type I collagen, and hyaluronan
- this is required for the movement of the tumor cell into the subendothelialstroma and subsequent growth at the secondary site of colonization.
- extracellular component laminin may contribute to a number of stages in tumour invasion and metastasis
- Increased expression of the laminin receptor has been associated with the metastatic phenotype of cancer cells
- Laminin , a potential serum tumour marker
- urokinase (uPA), a serine protease that is able to proteolytically degrade various (ECM) components and the basement membrane around tumour
- uPA cleaves plasminogen into plasmin which in turn activates MMP, 2, 3, 9, and 14 that further contribute to ECM degradation
- (TAMs) be abundantly present in the microenvironments of metastasizing tumors
- enhance tumor cell migration and intravasation by secreting chemotactic and chemokinetic factors, promoting angiogenesis, remodeling the Endothelium
- and regulating the formation of collagen fibers.
- and regulating the formation of collagen fibers.
- enhance tumor cell migration and intravasation by secreting chemotactic and chemokinetic factors, promoting angiogenesis, remodeling the Endothelium
- (TAMs) be abundantly present in the microenvironments of metastasizing tumors
- uPA cleaves plasminogen into plasmin which in turn activates MMP, 2, 3, 9, and 14 that further contribute to ECM degradation
- urokinase (uPA), a serine protease that is able to proteolytically degrade various (ECM) components and the basement membrane around tumour
- Laminin , a potential serum tumour marker
- Increased expression of the laminin receptor has been associated with the metastatic phenotype of cancer cells
- extracellular component laminin may contribute to a number of stages in tumour invasion and metastasis
- this is required for the movement of the tumor cell into the subendothelialstroma and subsequent growth at the secondary site of colonization.
- The final step is the adhesion of the metastatic tumor cell to connective tissue elements such as fibronectin, type I collagen, and hyaluronan
- followed by adherence to proteins of the subendothelial basement membrane, such as laminin and types IV and V collagen
- The first step in this process is specific adhesion to venular endothelial cells
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