Pyrimidine Metabolism

hardinbc
Mind Map by hardinbc, updated more than 1 year ago
hardinbc
Created by hardinbc almost 7 years ago
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Biochemistry Mind Map on Pyrimidine Metabolism, created by hardinbc on 05/01/2013.
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Resource summary

Pyrimidine Metabolism
1 Synthesis
1.1 glutamine
1.1.1 carbamoyl phosphate
1.1.1.1 urea cycle
1.1.1.2 committed step
1.1.1.3 N-carbamoylaspartate
1.1.1.3.1 dihydroorotate
1.1.1.3.1.1 orotate
1.1.1.3.1.1.1 + PRPP
1.1.1.3.1.1.2 orotidylate
1.1.1.3.1.1.2.1 UMPS
1.1.1.3.1.1.2.1.1 OPRT
1.1.1.3.1.1.2.1.2 ODC
1.1.1.3.1.1.2.2 UMP
1.1.1.3.1.1.2.2.1 UTP
1.1.1.3.1.1.2.2.1.1 CTP
1.1.1.3.1.1.2.2.1.2 CTP synthetase
1.1.1.3.1.1.2.2.1.2.1 + ATP
1.1.1.3.1.1.2.2.2 + ATP
1.1.1.3.1.2 NAD+ --> NADH
1.1.1.3.2 dehydration
1.1.1.4 + aspartate
1.1.1.4.1 aspartate transcarbamoylase
1.1.2 CPS II
1.1.2.1 cytosol
1.1.2.2 2 ATP
1.2 salvage pathway
1.2.1 thymidine kinase
1.2.1.1 thymidine + ATP
1.2.1.1.1 TMP + ADP
1.2.1.2 deoxyuridine + ATP
1.2.1.2.1 dUMP + ADP
1.2.2 uridine phosphorylase/uridine kinase
1.2.2.1 uracil + ribose-1-p
1.2.2.1.1 uridine + Pi
1.2.2.2 uridine + ATP
1.2.2.2.1 UMP + ADP
1.2.3 deoxycytidine kinase
1.2.3.1 deoxycytidine + ATP
1.2.3.1.1 dCMP + ADP
2 Deoxyribonucleotides
2.1 NDP
2.1.1 dNDP
2.1.2 ribonucleotide reductase
2.1.2.1 thioredoxin
2.1.2.1.1 NADPH reduces
2.1.2.2 (-) hydroxyurea
2.1.2.3 (+) ATP, (-) dATP
2.1.2.3.1 metabolic state
2.1.2.4 allosteric
2.1.2.4.1 dTTP, dGTP, dATP
2.2 dUMP
2.2.1 dTMP
2.2.1.1 + dihydrofolate
2.2.2 thymidylate synthase
2.2.3 + N5,N10-methylenetetrahydrofolate
2.2.3.1 donates CH3
3 Regulation of Synthesis
3.1 cytoplasmic CPSII
3.2 inhibition
3.2.1 UTP
3.2.2 CTP
3.3 stimulation
3.3.1 ATP
3.3.2 PRPP
4 Catabolism
4.1 ultimate products
4.1.1 B-alanine
4.1.1.1 CMP or UMP
4.1.2 B-aminoisobutyrate
4.1.2.1 dTMP
4.1.3 CO2
4.1.4 NH3
4.2 alanine
4.2.1 malonyl-CoA
4.2.1.1 FA synthesis
4.3 aminoisobutyrate
4.3.1 methyl malonyl-CoA
4.3.1.1 succinyl-CoA
4.3.1.1.1 TCA cycle
4.4 DPD
4.4.1 initial/RLS
4.4.1.1 reduction of U or T
4.4.1.2 also degrades
4.4.1.2.1 5-fluorouracil
4.4.1.2.2 tegafururacil
5 Functions of Nucleotides
5.1 precursors for DNA/RNA
5.2 metabolism
5.2.1 ATP/GTP
5.2.2 SAM, UDP sugar, CDP choline
5.2.3 cAMP/cGMP
5.3 coenzymes
5.3.1 NADH
5.3.2 FAD
5.3.3 CoA
6 Disorders
6.1 UMP synthase deficiency
6.1.1 hereditary orotic aciduria
6.1.2 function
6.1.2.1 catalyze decarbox rxn
6.1.2.1.1 orotate phosphoribosyltransferase
6.1.2.1.2 orotidine-5'-monophosphate decarboxylase
6.1.3 orotic acid accumulates
6.1.3.1 megablastic anemia
6.1.3.2 orotic crystalluria
6.1.3.3 nephropathy
6.1.3.4 cardiac malformations
6.1.3.5 strabismus
6.1.3.6 recurrent infections
6.1.4 autosomal
6.1.4.1 recessive
6.1.5 dagnosis
6.1.5.1 enzyme assay
6.1.5.1.1 various tissues
6.1.6 treatment
6.1.6.1 oral uridine
6.2 DPD deficiency
6.2.1 autosomal
6.2.1.1 recessive
6.2.2 function
6.2.2.1 metabolism of uracil/thymine
6.2.3 develop severe toxicity
6.2.3.1 when exposed to 5-FU
6.2.3.1.1 chemotherapy drug
6.2.3.1.2 also Xeloda
7 Drugs
7.1 cancer treatment
7.1.1 thymidine analog
7.1.1.1 inhibition
7.1.1.1.1 thymidylate synthase
7.1.1.2 F replace CH3
7.1.1.3 prevent DNA replication
7.2 HIV
7.2.1 derivatives of nucleosides
7.2.1.1 AZT
7.2.1.1.1 chronic use
7.2.1.1.1.1 compromised mitos
7.2.1.2 ddC, 3TC, ddI, d4T
7.2.1.3 cellular kinase
7.2.1.3.1 triphosphate
7.2.1.3.2 metabolism
7.2.1.3.2.1 inhibition
7.2.1.3.2.1.1 HIV reverse transcriptase
7.2.1.3.2.1.2 chain termination
7.2.1.3.2.1.2.1 incorporate AZT or DDC
7.2.1.3.2.1.2.1.1 growing 3' end
7.2.1.3.2.1.2.1.1.1 truncate DNA chain
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