Anti-Fungals

CharlottyBow
Mind Map by CharlottyBow, updated more than 1 year ago
CharlottyBow
Created by CharlottyBow about 7 years ago
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Bsc Antifungal Mind Map on Anti-Fungals, created by CharlottyBow on 05/14/2013.
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Anti-Fungals
1 Pyrimidines
1.1 5 Fluorocytosine
1.1.1 5-Fluorouracil
1.1.1.1 FUTP
1.1.1.1.1 Fluorodine Triphosphate
1.1.1.1.1.1 Incorporated into RNA
1.1.1.2 FdUMP
1.1.1.2.1 Thymidine synthetase
1.1.1.2.1.1 Inhibits DNA synthesis
1.1.1.3 Cryptococcus
1.1.1.3.1 Most Candida
1.1.2 Taken up by fungal specific cytosine permease
2 Polyenes
2.1 Nystatin
2.1.1 Topical
2.1.2 Oral and Vaginal Candidosis
2.2 Amphotericin B
2.2.1 Broad spectrum empirical
2.2.2 IV 1x
2.2.3 Lipid ambisome
2.3 Bind sterols causing membrane breakage
3 Echocandins
3.1 Anidulafungin
3.1.1 headache, nausea, liver
3.2 Micafungin
3.2.1 headache, liver
3.3 Caspofungin
3.3.1 Hypookalemia, fever, chillls, liver
3.3.1.1 High conc, paradoxical effect
3.4 Bind to Fksp1 subunit of B-1-3-D glugan synthesis
3.4.1 Component of fungal synthase
3.5 IV 1x
3.6 aspergillus and most candida
4 Terbafine
4.1 Tinea infections
4.1.1 Capitis
4.1.2 Pedis
4.1.3 Corporis
4.1.4 Curis
4.2 Oral 1x
4.3 Tablets, cream, spray
4.4 altered liver function and taste perception
4.5 Inhibits squalene epoxidase (ergosterol)
5 Azoles
5.1 Imidazoles
5.1.1 Ketconazole
5.1.2 Topical
5.1.3 Superficial Skin Infections
5.1.4 Clotimazole
5.1.5 Econazole
5.1.6 Miconazole
5.2 Triazoles
5.2.1 Posconazole
5.2.1.1 Oral 3-4x
5.2.1.1.1 Aspergillus
5.2.1.1.1.1 Fusarium
5.2.1.1.1.1.1 coccididiomycosis
5.2.2 Fluconazole
5.2.2.1 Oral/IV 1x
5.2.2.1.1 Crypto, men.
5.2.2.1.1.1 Candida
5.2.2.1.1.1.1 coccididiomycosis
5.2.3 Itraconazole
5.2.3.1 Oral/IV 2-4x
5.2.3.1.1 Aspergillus
5.2.3.1.1.1 Candida
5.2.3.1.1.1.1 Cryptococcus
5.2.3.1.1.1.1.1 Histoplasmosis
5.2.4 Voricaonzole
5.2.4.1 Oral/IV 2x
5.2.4.1.1 Aspergillus
5.2.4.1.1.1 Candida
5.2.4.1.1.1.1 Fusarium
5.2.4.1.1.1.1.1 Scedosporum
5.2.5 lanosterol-14-a- demethylase
5.2.5.1 Inhibits ergosterol production
5.2.5.1.1 conv of lanosterol to ergosterol
5.2.5.1.1.1 build up of methylsterols
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