Sana With Rash & Bruising

thrombopoiesis
1. Process by which mature platelets are generated within the bone marrow
Hemostasis
1. blood coagulation mechanism
  1. causes
2. bleeding disorders
  1. history taking
  2. investigations
  3. causes
    1. platelets
      1. qualitative
      2. quantitative
        Thrombocytopenia
        Idiopathic thrombocytopenic purpura
        lead to easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets
        Acute ITP: less than 6 months usually presents as a childhood
        Chronic ITP 6 months or longer occurs most commonly between the ages of 20 and 50 years
        secondary if it is associated with an underlying disorder; autoimmune disorders, particularly systemic lupus erythematosus (SLE), and infections, such as HIV and hepatitis C
        Risk FactorsGenetics Gender Age Receiving certain vaccines. Although very rare, some vaccinations can “trigger” ITP. Viral infections
        The signs of bleeding include: Petechiae (< 3mm) Purpura (3-10 mm) Ecchymoses (> 1 cm) Hematoma Nosebleeds or bleeding from the gums Blood in urine or stool
        treatment
        spleen
        Decreased production: Aplastic aneamia- megaloblastic anemia-drugs- infections (HIV), leukemia
        Decreased survival: immune thrombocytopenic purpura (ITP)-drug induced (heparin- quinidine)-Dissiminated intravascular coagulopathy (DIC)- thrombotic thrombocytopenic purpura (TTP)
    2. Coagulation factors
      1. types
    3. Vessel Wall
      1. Congenital defects of the vessel wall
      2. Senile purpura:
      3. Scurvy
      4. Septic Vasculitis
3. defect leads to

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Sana With Rash & Bruising

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	Created by rania khalil almost 7 years ago