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Mind map

Skin

Pip Barton BOD English

Map content

Skin

Role of skin
- Protection
- Sensation
- Thermoregulation
- Metabolic
Epidermal layers
- Cornified layer
  - Cornified envelope
    - Filaggrin
      - In disease
        FLG gene mutation
        Ichyosis vulgaris
      - Gene structure
        N terminal regulated enucleation
        Repeat segment = keratin bundling
        C terminal required for processing
      - Processing
        Stage 5: Fillagrin degraded by caspase 14
        N product amino acids as moisturisers
        Stage 1: Profiligrin in keratohyalin
        Stage 2: Rising Ca2+ starts processing
        Fillagrin releases
        Stage 3: Matriptase & prostasin
        Fillagrin processed
        Stage 4: Mature fillagrin bundles keratin
    - Assembly
      - Initial scaffold
        Periplakin
        Envoplakin
        Triple KO
        Affects cornified envelope
        Poor lipid
        Reduction in proteases
        Involucrin
        Transglutaminase 1
      - 2ndary
        Loricrin
        SPRR
        Transglutaminase 3
  - Lipid envelope
    - Importance
      - ABCA12 mutation
        Harlequin Ichtyosis
        Lipid transporter
  - Intercellular lamellae
    - Secreted by lamellar bodies
- Granular layer
  - Keratinocyte differentiation
    - Lose nucleus and organelles
    - secrete phospholipids
      - ceramide lipids
  - Tight junctions
    - Claudin1 deficiency
      - loss of water & TJ
- Spinous layer
- Basal layer

Information

Description: BOD Mind Map on Skin, created by Pip Barton on 16/05/2013.
Created by: Pip Barton
Views: 34
Tags: bod
History: Created by sam.hilton · May 16, 2013

Copied by Pip Barton · May 16, 2013
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