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Drugs at the Synapse

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Behavioural Neuroscience Mapa Mental sobre Drugs at the Synapse, criado por lynda_ashford_25 em 21-10-2013.
lynda_ashford_25
Mapa Mental por lynda_ashford_25, atualizado more than 1 year ago
lynda_ashford_25
Criado por lynda_ashford_25 mais de 10 anos atrás
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Resumo de Recurso

Drugs at the Synapse
  1. Antagonist- blocks a neurotransmitter
    1. Agonist- mimics or increases a neurotransmitter
      1. Drug Affinity- ability to bind to receptor
        1. Drug Efficacy- activate the receptor once bound. Can bind but then not activate (antagonist)
          1. Stimulant drugs
            1. Both amphetamine and cocaine block reuptake of dopamine, increasing the amount in the presynaptic terminal
              1. excitement, alertness, elevated mood, decreased fatigue
            2. Nicotine
              1. Stimulates nictotinic type acetylcholine receptors, which increases dopamine release in nucleus accumbens.
                1. mostly stimulant effects
              2. Opiates
                1. Act on receptors in the brain and mimic the effects of endorphins. This inhibits GABA which would otherwise inhibit dopamine, leading to an increase.
                  1. relaxation, withdrawal, decreased pain
                2. Marijuana
                  1. Two brain chemicals bind to canabinoid receptors called anadamide and sn-2 arachidomylglyrecol (2-AG). This inhibits further release of either glutamate or GABA
                    1. altered sensory expenses, decreased pain and nausea, increased appetite
                  2. Hallucinogenic
                    1. Attach to serotonin type 2A (5-HT2a) and provide stimulation.
                      1. distorted sensations
                    2. Alcohol
                      1. Blocks glutamate and facilitates GABA-A receptors. Can also release dopamine.
                        1. moderate amounts relax and decrease anxiety, large amounts impair judgement

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