Krebs cycle

Krebs cycle

1. Involves series of oxidation-reduction reactions

2. Occurs in matrix of mitochondria

3. 2C acetylCoA from link reaction combines with 4C to produce 6C molecule

   • 6C molecule loses CO2 and Hs to give a 4C molecule and single ATP produced as a result of Substrate-level phosphorylation
     • 4C molecule combines with new molecule of acetylCoA to begin new cycle again

4. For each molecule of pyruvate(of 2 produced from glucose) together with link reaction produces

   • Reduced coenzymes: NAD and FAD
     • Has potential to produce ATP 
   • 1 ATP
   • 3 CO2

5. Coenzymes-molecules that some enzyme require in order to function

   • They carry H atoms from one molecule to another
   • NAD in respiration works with dehydrogenase enzyme- catalyse the removal of H ions from substrates and transfer them to other molecules;H carriers

6. Breaks down macromolecules into smaller ones;pyruvate=>CO2

7. Produces H atoms that are carried by NAD to the electron transport chain for oxidative phosphorylation

   • Leads to production of ATP

8. Regenerates the 4C molecule that combines with acetylCoA(otherwise it would accumulate)

9. A source of intermediate compounds used by cells in the manufacture of other important substances(fatty acids,amino acids, chlorophyll)