innate immunity

innate immunity

1. Physical barriers

   • skin
   • mucosa
   • cilia

2. Chemical Barriers

   • Phagocytes
     • acidification
     • ROIs - free radicals
       • NADPH oxidases
       • CGD- cannot produce ROIS
     • Nitrogen oxides

3. microbiota

4. Inflammatory response

   • cytokines cause vasodilation
     • TNF and IL-1 make endothelium sticky
       • Septic shock

5. Antigens and receptors

   • Complement system
     • Classical pathway
       • Requires antibodies to activate
         • Recruitment of inflammatory and immunocompetent cells
     • Alternative pathway
       • Killing of pathogens
     • Lectin pathway
       • Opsonization of pathogens
   • LPS
     • TLR4
   • Lipoprotein
     • TLR2
   • Flagellin
     • TLR5
   • Beta glucans
     • TLR2
   • Mannose
     • TLR2
     • Lectin
   • Viral RNA
     • In cytosol
       • RIG-I
       • MDA5
     • Extracellular
       • TLRs

6. Cytokines

   • ILs
   • TNFs
   • Type 1 interferons