Quiz
PHSI3012 10-1 Disorders of Lipid Metabolism #1 (T3L1)
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Perguntas do quiz (12)
1How many ATPs go where?
(btw, "1 ATP" goes before "1ATP")
- A2 ATP
- B2ATP
- CATP
- D4 ATP
- E36 ATP
- F129 ATP
2Free fatty acids (NEFA / Non-Esterified Fatty Acids) vs TriAcylGlycerides (/TAGs).
[blank_start]__________[blank_end] circulate bound to albumin.
[blank_start]__________[blank_end] circulate within [blank_start]__________[blank_end] released from the liver or [blank_start]__________[blank_end] released from the gut.- ANEFA
- BTAGs
- CVLDLs
- DChylomicrons
3Lipid uptake.
Put the three in order (they’re written alphabetically here)
[blank_start]__________[blank_end] Cholesterol-rich LDL interact with LDL-R and scavenger receptors; enters lysosomal pathway for hydrolysis;
[blank_start]__________[blank_end] Hepatic Lipase and Lipoprotein Lipase reside on endothelial cells to hydrolyse VLDL and Chylomicron TAG to FFAs for uptake;
[blank_start]__________[blank_end] TAG-rich VLDL interact with VLDL-R, enters lysosomal pathway where acid lipases hydrolyse TAG.- AStage 3
- BStage 1
- CStage 2
4Familial Lipoprotein Lipase Deficiency is:
- AAutosomal DOMINANT
- BAutosomal RECESSIVE
5LPL deficiency causes [blank_start]__________[blank_end], which leads to [blank_start]__________[blank_end].
- AAccumulation of Chylomicrons
- BAccumulation of LDLs
- CAccumulation of HDLs
- DAccumulation of VLDLs
- EHypertriglyceridaemia
- FHypotriglyceridaemia
6Fatty Acid Metabolism has two major pathways: TriAcylGlycerol metabolism and β-Oxidation.
FA uptake is a 2-step process. In which order does it happen?- ATransport by FA transporters >> Activation by Acyl-CoA Synthetases
- BActivation by Acyl-CoA Synthetases >> Transport by FA transporters
7FA activation:
- AConsumes 1 ATP
- BIs irreversible
- CIs reversible
- DConsumes 2 ATP
- EConsumes 4 ATP
- FConsumes 36 ATP
8De Novo Fatty Acid Synthesis uses [blank_start]__________[blank_end] (from Glucose and Amino acids) to generate [blank_start]__________[blank_end] as the starting substrate to firstly produce [blank_start]__________[blank_end] (C16:O).
- ACitrate
- BAcetyl-CoA
- CMalonyl-CoA
- DPalmitate
9De Novo Fatty Acid Synthesis uses up how many ATP molecules?
- A1
- B2
- C7
- D36
10CPT1 turns Carnitine into FA-Carnitine, allowing it to be uptaken into a cell. This can be blocked by which of the following?
- AMalonyl-CoA
- BAcetyl-CoA
11MCD deficiency (and some similar disorders) prevent [blank_start]__________[blank_end] from being turned into [blank_start]__________[blank_end]. This results in [blank_start]__________[blank_end] of CPT1 (and thus [blank_start]__________[blank_end] FA uptake).
- AMalonyl-CoA
- BAcetyl-CoA
- CBlockage
- DStimulation
- EReduces
- FIncreases
12What goes where?
(within each box, put the two in alphabetical order)
- AAdipose-derived Fatty Acids
- BChylomicron-derived Fatty Acids
- CDe novo Lipogenesis
- DRe-esterification
- EFatty Acid Oxidation
- FTAG Secretion (e.g. VLDL)
Informações
- Descrição
- PHSI3012 10-1 Disorders of Lipid Metabolism #1 (T3L1)
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- English
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- Criado em 24 nov 2017 · atualizado em 24 nov 2017
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