Integral Membrane Proteins

Descrição

Structural Basis for Biological Function (Membrane Proteins) Quiz sobre Integral Membrane Proteins, criado por gina_evans0312 em 14-12-2013.
gina_evans0312
Quiz por gina_evans0312, atualizado more than 1 year ago
gina_evans0312
Criado por gina_evans0312 mais de 10 anos atrás
510
1

Resumo de Recurso

Questão 1

Questão
5% of the human genome is genes that add a phosphate to something using ATP (Kinases)
Responda
  • True
  • False

Questão 2

Questão
Which of the following residues can be phosphorylated by kinases?
Responda
  • Serine
  • Threonine
  • Tyrosine
  • Valine
  • Argenine
  • Glutamic Acid

Questão 3

Questão
How many different kinases are there (roughly)?
Responda
  • 510
  • 520
  • 530

Questão 4

Questão
In kinases, DFG & RC motifs are highly conserved
Responda
  • True
  • False

Questão 5

Questão
Which domains are commonly found in kinase interacting proteins?
Responda
  • SH1
  • SH2
  • SH3

Questão 6

Questão
SH3 proteins mediate the assembly of proteins structures by binding to proline rich peptides in them
Responda
  • True
  • False

Questão 7

Questão
SH domains modulate protein interactions by recognizing and binding to specific proteins by identifying specific peptide sequences
Responda
  • True
  • False

Questão 8

Questão
What is the role of PH domains?
Responda
  • Binding the protein to the ER membrane
  • Binding the protein to the cell membrane
  • Binding the protein to nuclear membrane

Questão 9

Questão
Membranes form what?
Responda
  • Compartments & permeability barriers
  • Compartments & osmotic barriers

Questão 10

Questão
What mediate membrane functions?
Responda
  • Proteins
  • Glycolipids
  • Phospholipid concentration

Questão 11

Questão
Mitochondiral membranes contail the most proteins, plasma membranes contain the least (Out of Mitochondrial, Plasma and Myelin membranes)
Responda
  • True
  • False

Questão 12

Questão
Most integral membrane proteins span the membrane
Responda
  • True
  • False

Questão 13

Questão
Integral proteins interact extensively with what?
Responda
  • The hydrocarbon chains of lipids
  • The phosphate groups of phospholipids
  • The hydrocarbon tails of phospholipids

Questão 14

Questão
Peripheral proteins are bound to the membrane via the head groups of phospholipids
Responda
  • True
  • False

Questão 15

Questão
How do we tell how strongly a membrane protein is associated?
Responda
  • Try and disassociate it using detergent
  • Try and disassociate it using water

Questão 16

Questão
Baterial Rhodopsin uses heat to pump protons out of the membrane
Responda
  • True
  • False

Questão 17

Questão
How is the hydrophobic core formed in baterorhodopsin?
Responda
  • 7 alpha helices
  • 7 beta sheets
  • 3 alpha helices, 4 beta sheets

Questão 18

Questão
In the case of the highly conserved 'Membrane Spanning Alpha Helix Structure', what must be on the outside?
Responda
  • Phospholipids
  • Non-polar aa
  • Polar aa

Questão 19

Questão
The membrane spanning alpha helix structure acts as what?
Responda
  • A scaffold for the active site
  • The active site
  • The channel for the active site to move through

Questão 20

Questão
Transmembrane helices can be predicted by a long string (or more) of hydrophobic amino acids in their aa sequence
Responda
  • True
  • False

Questão 21

Questão
What is used to estimate the free energy change of a residue on transfer of a residue to water (i.e. how much energy does it take to disassociate the aa from the protein)?
Responda
  • A polarity scale
  • An amino scale
  • A pH scale

Questão 22

Questão
An amino acid with high energy lies buried in a hydrophobic region i.e. the membrane
Responda
  • True
  • False

Questão 23

Questão
How large is the hydrocarbon core of the membrane?
Responda
  • 30A
  • 32A
  • 34A

Questão 24

Questão
What is the name of the 20aa section of an integral protein that spans the membrane?
Responda
  • Pocket
  • Window
  • Scaffold

Questão 25

Questão
How is a Hydropathy plot formed?
Responda
  • The free energy change for each 20 aa segement plotted against the first aa in each segment
  • The free energy change for each 20 aa segement plotted against the last aa in each segment
  • The free energy change for each 30 aa segement plotted against the first aa in each segment

Questão 26

Questão
What is the point of a hydropathy plot?
Responda
  • To find which aa are in hydrophobic areas
  • To find the window of integral proteins
  • To find the window of peripheral proteins

Questão 27

Questão
The criterion level for a hydropathy plot is +68
Responda
  • True
  • False

Questão 28

Questão
What is Porin an example of?
Responda
  • Membrane spanning alpha helices
  • Membrane spanning beta sheets
  • Membrane spanning helix/beta sheet structure

Questão 29

Questão
What tends to be the features of membrane spanning beta sheet residues?
Responda
  • Hydrophobic
  • Hydrophillic
  • Alternating hydrophobic and hydrophilic

Questão 30

Questão
The polarity of the internal aa in a membrane spanning beta sheet depends on the size
Responda
  • True
  • False

Questão 31

Questão
Each sheet in the m.s beta sheet arrangement is hydrogen bonded to its neighbor in a parallel manner
Responda
  • True
  • False

Semelhante

Chemiosmosis
gina_evans0312
Alternative Oxidase
gina_evans0312
Prostaglandin Synthase & Multi-Enzyme Complexes
gina_evans0312
Electron Transport Chain
gina_evans0312
Cyt C Oxidase & F1F0
gina_evans0312
Oxidation Practical
gina_evans0312
Protein Folding- The Basics
gina_evans0312
Molecular Motors- Helicases
gina_evans0312
Constituative Chaperones
gina_evans0312
Chaperonins
gina_evans0312
Heat Shock Proteins
gina_evans0312