Questão 1
Questão
5% of the human genome is genes that add a phosphate to something using ATP (Kinases)
Questão 2
Questão
Which of the following residues can be phosphorylated by kinases?
Responda
-
Serine
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Threonine
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Tyrosine
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Valine
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Argenine
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Glutamic Acid
Questão 3
Questão
How many different kinases are there (roughly)?
Questão 4
Questão
In kinases, DFG & RC motifs are highly conserved
Questão 5
Questão
Which domains are commonly found in kinase interacting proteins?
Questão 6
Questão
SH3 proteins mediate the assembly of proteins structures by binding to proline rich peptides in them
Questão 7
Questão
SH domains modulate protein interactions by recognizing and binding to specific proteins by identifying specific peptide sequences
Questão 8
Questão
What is the role of PH domains?
Responda
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Binding the protein to the ER membrane
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Binding the protein to the cell membrane
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Binding the protein to nuclear membrane
Questão 9
Questão
Membranes form what?
Questão 10
Questão
What mediate membrane functions?
Questão 11
Questão
Mitochondiral membranes contail the most proteins, plasma membranes contain the least (Out of Mitochondrial, Plasma and Myelin membranes)
Questão 12
Questão
Most integral membrane proteins span the membrane
Questão 13
Questão
Integral proteins interact extensively with what?
Responda
-
The hydrocarbon chains of lipids
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The phosphate groups of phospholipids
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The hydrocarbon tails of phospholipids
Questão 14
Questão
Peripheral proteins are bound to the membrane via the head groups of phospholipids
Questão 15
Questão
How do we tell how strongly a membrane protein is associated?
Questão 16
Questão
Baterial Rhodopsin uses heat to pump protons out of the membrane
Questão 17
Questão
How is the hydrophobic core formed in baterorhodopsin?
Questão 18
Questão
In the case of the highly conserved 'Membrane Spanning Alpha Helix Structure', what must be on the outside?
Responda
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Phospholipids
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Non-polar aa
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Polar aa
Questão 19
Questão
The membrane spanning alpha helix structure acts as what?
Questão 20
Questão
Transmembrane helices can be predicted by a long string (or more) of hydrophobic amino acids in their aa sequence
Questão 21
Questão
What is used to estimate the free energy change of a residue on transfer of a residue to water (i.e. how much energy does it take to disassociate the aa from the protein)?
Responda
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A polarity scale
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An amino scale
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A pH scale
Questão 22
Questão
An amino acid with high energy lies buried in a hydrophobic region i.e. the membrane
Questão 23
Questão
How large is the hydrocarbon core of the membrane?
Questão 24
Questão
What is the name of the 20aa section of an integral protein that spans the membrane?
Questão 25
Questão
How is a Hydropathy plot formed?
Responda
-
The free energy change for each 20 aa segement plotted against the first aa in each segment
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The free energy change for each 20 aa segement plotted against the last aa in each segment
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The free energy change for each 30 aa segement plotted against the first aa in each segment
Questão 26
Questão
What is the point of a hydropathy plot?
Responda
-
To find which aa are in hydrophobic areas
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To find the window of integral proteins
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To find the window of peripheral proteins
Questão 27
Questão
The criterion level for a hydropathy plot is +68
Questão 28
Questão
What is Porin an example of?
Responda
-
Membrane spanning alpha helices
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Membrane spanning beta sheets
-
Membrane spanning helix/beta sheet structure
Questão 29
Questão
What tends to be the features of membrane spanning beta sheet residues?
Questão 30
Questão
The polarity of the internal aa in a membrane spanning beta sheet depends on the size
Questão 31
Questão
Each sheet in the m.s beta sheet arrangement is hydrogen bonded to its neighbor in a parallel manner