Quiz
Mammalian Biochemistry Class Test Prep
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Perguntas do quiz (60)
1Which of these is not a function of blood?
- ATransport of nutrients
- BTransport of signals (hormones etc)
- CHeat distribution
- DHormone production
2Which of these inorganic ions are not found in plasma?
- ANa+
- BCl-
- CK+
- DMg2+
3Which of these is not a component of plasma?
- AWater
- BSmall organics
- CProteins
- DRed blood cells
4How much water is contained in plasma?
- A5-5.5L
- B5.5-6L
- C4.5-5L
- D6-6.5L
5Which is the most abundant serum protein?
- AAlbumin
- Bα1-globulins
- Cβ-globulins
- Dγ-globulins
6What is the normal range of protein concentration in serum?
- A60-80 g/L
- B50-70 g/L
- C70-90 g/L
- D40-60 g/L
7What are the approximate proportions of Albumin?
- A~55%
- B~60%
- C~50%
- D~65%
8What is the approximate proportion of immunoglobulin G?
- A~15%
- B~20%
- C~10%
- D~25%
9Which of these is not involved in blood clotting?
- AAlbumin
- BThrombin
- CFibrin
- DPlasmin
10Which of these is a 66kDa polypeptide with 3 homologous domains each with different binding sites?
- AAlbumin
- Bα1-Proteinase Inhibitor
- CTransferrin
- DHaemoglobin
11Which of the following is a 54kDa polypeptide with a 'bait' sequence for elastase binding?
- Aα1-Proteinase Inhibitor
- BAlbumin
- CTransferrin
- DHaemoglobin
12Which of the following is a 77kDa polypeptide with 2 homologous domains each with an Fe binding site
- ATransferrin
- BAlbumin
- Cα1-Proteinase Inhibitor
- DHaemoglobin
13Which of the following is not a Granulocyte
- ANeutrophils
- BEiosinophils
- CBasophils
- DLymphocytes
14How many molecules of Haemoglobin are there in a red blood cell?
- A250x10^6
- B250x10^8
- C250x10^7
- D250x10^5
15Which of the following is not present in a red blood cell?
- AMitochondria
- BCytoskeleton
- CHaemoglobin
- DCell Membrane
16Which of the following is a 64kDa tetrapolypeptide with 2 α-chains and 2 β-chains?
- AHaemoglobin
- BAlbumin
- CTransferrin
- Dα1-Proteinase Inhibitor
17What percentage of humans have a Haemoglobin mutation?
- A1%
- B5%
- C7%
- D9%
18Which of the following is not a main role of pattern recognition receptors?
- ATo activate the cell to synthesise
- BTo cause cells to release defensive molecules
- CTo initiate phagocytosis or apoptosis
- DTo carry out phagocytosis or apoptosis
19Which of the following carries out phagocytosis
- ANeutrophils
- BLymphocytes
- CBasophils
- DEosinophils
20Which of the following is not an anti microbial enzyme?
- ALysozyme
- BLacoperioxidase
- CPhopholipase A2
- DSuperoxide dismutase
21What is the size of anti-microbial peptides?
- A3-5kDa
- B2-4kDa
- C4-6kDa
- D5-7kDa
22Which of the following is not an anti-microbial peptide?
- ADefensins
- BHistatins
- CCathelicidins
- DTransferrins
23Which of the following is not a feature of adaptive immunity?
- ASpecificity
- BMemory
- CTolerance
- DRapid 1st Response
24Which of the following is regarded as a type of lympocyte
- AB cell
- BT cell
- CBoth B and T cell
- DNeither B or T cell
25In vaccination, which of these methods is not used?
- AUsing a related organism
- BUsing a wild type strain
- CUsing a recombinent antigen
- DUsing an attenuated strain
26Which of the following is a 150kDa tetrapolypeptide with 2 heavy amd 2 light chains
- AIgG
- BHaemoglobin
- CAlbumin
- DTransferrin
27IgG is made up of...
- A2 50kDa chains and 2 25kDa chains
- B1 75kDa chain and 3 25kDa chains
- C2 75kDa chains
- D3 50kDa chains
28Which of these is a correct arrangement for polypeptide chains in IgG
- Aγ2λ2
- Bλ2κ2
- Cγ2κλ
- Dγ2γ2
29How many Complementary-Determining Regions are there in a IgG molecule?
- A12
- B10
- C8
- D6
30Which of the following contains 2 heavy chains (α) and two light chains (λ or κ)
- AIgA
- BIgM
- CIgD
- DIgE
31Which of the following has 2 heavy chains (µ) and two light chains (λ or κ)
- AIgA
- BIgM
- CIgD
- DIgE
32Which of the following has 2 heavy chains (δ) and two light chains (λ or κ)
- AIgA
- BIgM
- CIgD
- DIgE
33Which of the following has 2 heavy chains (ε) and two light chains (λ or κ)
- AIgA
- BigD
- CIgM
- DIgE
34The V domains on all the heavy chains are specified by
- AV segment
- BV and D segments
- CV, D and J segments
- DV and J segments
35The V domains on all the light chains are specified by
- AV segment
- BV and D segments
- CV, D and J segments
- DV and J segments
36Which of the following is false regarding Antibody-mediated immunity?
- ADirected towards extracellular antigens.
- BRecognition by BCRs on the B-cells.
- CRequires confirmation by Th-cells for antibody production
- DDirected towards intracellular antigens.
37Which of the following statements regarding the MHC I and MHC II systems is false?
- AThe are both highly polymorphic.
- BBoth require 3 types of peptides
- CIndividuals commonly have the same combination of MHC proteins
- DThe binding sites of the MHC proteins recognise sets of peptides
38Which of the following statements regarding T-cells is false?
- AFrom bone marrow
- BMature in bone marrow
- CThere are two types
- DMature T-cells circulate and reside in lymphoid tissue
39Which of the following statements is false?
- AAll mitochondria come from the mother
- BMitochondria have their own DNA
- CMitochondria is found in all cell types
- DMitochondria is involved with apoptosis
40The body daily produces approximately...
- A70kg ATP
- B60kg ATP
- C80kg ATP
- D100kg ATP
41What % of mitochondrial disorders are due to mtDNA mutations?
- A10
- B15
- C20
- D25
42Which of the following statements regarding mtDNA is false?
- AContains no introns
- BContains a repair mechanism
- CContains no repeats
- DDouble stranded, circular
43Which of the following can't be used for mitochondrial disease diagnosis
- AMaternal family history
- BBlood/CSF/Urine tests
- CImaging Techniques
- DPaternal family history
44Which mitochondrial disease has a very early onset of symptoms?
- ALeigh Syndrome
- BLeber's hereditary optic neuropathy
- CMELAS
- DOphthalmoplegia
45Which disorder is associated with "Ragged Red Fibers"
- AMERRF
- BNARP
- CMELAS
- DPearson syndrome
46Which of the following is not a radical?
- AHydrogen peroxide
- BHypoclorite
- CSinglet oxygen
- DPeroxynitrite
47Which is the most reactive intermediate?
- AHydroxyl radicals
- BSuperoxide
- CHydrogen Peroxide
- DPeroxynitrite
48Which is the least reactive intermediate?
- AHydrogen peroxide
- BHydroxyl radicals
- CSuperoxide
- DPeroxynitrite
49Which is not a source of superoxide?
- AEnzymatic
- BToxic compounds
- CIonising Radiation
- DUV light
50What enzyme is used to detoxify hydrogen peroxide?
- ACatalase
- BSuperoxide dismutase
- CHydrogen peroxidase
- DHydrogen dismutase
51(From Textbook) The production of antibodies in response to a foreign molecule is referred to as
- Aa cellular immune response
- Ba humoral immune response
- Can autoimmune response
52(From textbook) An epitope is
- Athe portion of an antibody which recognizes an antigen.
- Bthe protein of an antigen recognized by an antibody.
- Can internal signal in the B-lymphocytes initiating the production of antibodies.
53(From textbook) The treatment of immunoglobulin G with papain results in the production of two types of fragments. Which of the following correctly relates these fragments to antigen binding?
- AThe Fab fragment is capable of binding antigen but the Fc fragment is not.
- BThe Fab fragment can bind antigen only in the presence of the Fc fragment.
- CThe proteolytic action of papain abolishes the ability of the antibody fragments to bind antigen.
54(From textbook) The immunoglobulin G molecule is composed of two heavy (H) and two light (L) chains. Which of the following is true regarding the relationship between these two types of chains and the Fab and Fc fragments?
- AThe L chains are present only in the Fab fragment
- BThe Fc fragment contains parts of both the H and L chains
- CDisulfide bonds linking H and L chains are found in both Fab and Fc fragments.
55(From textbook) Hypervariable loops of the Fab portion of antibody molecules are involved in antigen binding. The amino acids forming these loops
- Acome from the L chain only.
- Bcome from the H chain only.
- Ccome from both the H and L chains.
56(From textbook) Genes for specific immunoglobulins are the product of rearrangement and linkage of V (variable) and C (constant) genes in the differentiation of lymphocytes. How does this process differ for the H and L chains?
- AJ (joining) genes are used to link V and C genes in construction of genes for L chains but not H chains.
- BD (diversity) genes are used in place of J genes in construction of genes for H chains.
- CD (diversity) genes are used in conjunction with J genes in construction of genes for H chains.
57(From textbook) T-cells scan the surface of cells and kill those that exhibit foreign markings. The form in which such cells are marked is
- Aby proteins from intracellular pathogens being secreted by the target cells
- Bby proteolytic products of intracellular pathogens being released from the target cells
- Cby proteolytic products of intracellular pathogens being presented on the surface of the cells bound to the major histocompatibility complex.
58(From textbook) Helper T cells also recognize foreign peptides displayed on the surface of cells in a complex with Class II MHC proteins. These peptides are the result of
- Adegradation of an internal pathogen located in the cytosol.
- Bdegradation of proteins internalized by endocytosis.
- Cforeign proteins being degraded by extracellular proteases
59(From textbook) The human immunodeficiency virus (HIV) responsible for acquired autoimmune deficiency syndrome (AIDS) subverts the immune system by destroying what type of cell?
- AB-lymphocytes
- Bkiller T cells
- Chelper T cells
60(From textbook) Thymocytes are produced in the bone marrow and converted to T cells in the thymus. Which of the following is NOT a selective process involved in this conversion?
- APositive selection to assure that only T cells that bind MHC proteins will survive.
- BNegative selection to assure that T cells that bind MHC proteins too tightly will be destroyed.
- CSelection to assure that T cells bind to MHC proteins only in the presence of foreign peptides.
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- Preparation for a class test using self made questions
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- MatthewEllis96
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- English
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