Quiz
Biochemistry Exam 6- 2nd Year, 2nd Semester- PMU
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Perguntas do quiz (39)
1Which of the following hormones derive from amino acids?
- Aestradiol
- Bepinephrine
- Cthyroid hormones
- Dcalcitriol
- Edopamine
2Which of the following statements about hyperthyroidism are TRUE?
- Athe blood levels of TSH are higher
- Bhypoglycemia
- Chyperglycemia
- Dincreased thermogenesis
- Edecreased thermogenesis
- Fthe blood levels of TSH are lower
3List at least three groups of plasma membrane receptors
1) [blank_start]Ion[blank_end] channels
2) [blank_start]G[blank_end]-[blank_start]Protein[blank_end] coupled receptor
3) [blank_start]Death[blank_end] receptors- AIon
- BG
- CProtein
- DDeath
4G protein-coupled receptors
- Aare associated with monomeric G-proteins
- Bare receptors for lipophilic hormones
- Ctransmit the signal of epinephrine and glucagon
- Dhave an intracellular domain rich in tyrosine
5Which of the following statements are NOT TRUE?
- Aglucocorticoids are synthesized in zona glomerulosa of the adrenal gland
- Badrenal androgens are DHEA and 5-dihydrotestosterone
- C5-dihydrotestosterone is more potent androgen than testosterone
- Drenin stimulates the conversion of angiotensin 1 into angiotensin 2
- E17-hydroxylase is the principle regulatory enzyme in streroidogenesis
6List at least 3 second messengers in the process of signal transduction
1) cyclic [blank_start]AMP[blank_end]
2) cyclic [blank_start]GMP[blank_end]
3) [blank_start]calcium[blank_end]- AAMP
- BGMP
- Ccalcium
7Which of the following statements about hypothyroidism are TRUE:
- Athe blood levels of TSH are lower
- Bthe blood levels of TSH are higher
- Cincreased thermogenesis
- Ddecreased thermogenesis
- Eunchanged metabolic rate
8Which of the following statements are NOT TRUE?
- ACYP 450 side chain cleavage enzyme is the key regulatory enzyme in the synthesis of all the steroid hormones
- B25-dehydrogenase is the main regulatory enzyme in the synthesis of calcitriol
- Ccalcitriol causes a decrease of blood Ca2+ levels
- Dcortisol has a prominent hyperglycemic effect
9Which of the following statements are TRUE:
- Atestosterone is less potent androgen than 5-dihydrotestosterone
- Bglucocorticoids are synthesized in zona fasciculata of the adrenal gland
- Cangiotensin ll stimulates the production of aldosterone in zona glomerulosa of the adrenal gland
- Dtestosterone is converted into estradiol by 17-ketoreduetase (17β- dehydrogenase)
10Based on their chemical composition hormones are:
- Apeptide
- Bautocrine
- Cparacrine
- Dsteroid
- Ederivatives of amino acids
11Which of the following statements are TRUE:
- Aphosphodiesterase is inhibited by insulin
- Bepinerphrine and ACTH use cAMP as a second messenger
- Cinsulin uses PI3K signaling pathway
- Dguanylyl cyclase activates protein kinase C (PKC)
12Which of the following hormones are secreted by anterior pituitary gland:
- AACTH
- BTSH
- CAngiotensin 2
- DAntidiuretic hormone (ADH)
- EProlactin
13Which of the following enzymes are involved in the biosynthesis of corticosteroids the adrenal cortex:
- A21-hydroxylase
- B1-α-hydroxylase
- C3-hydroxysteroid dehydrogenase and Δ5,4-isomerase
- Dcyt. P450 side chain cleavage enzyme (P450scc)
- E5-α-reductase
14Which of the following is NOT TRUE:
- ACholesterol side chain cleavage by P450 scc results in production of pregnolone
- BCortisol is produced in zone fasciculata
- CAldosterone is produced in zona reticularis
- DEstrogens biosynthesis requires aromatase activity
15Which of the following is NOT TRUE:
- AThyroid hormones are made from tyrosine
- BThe synthesis of thyroid hormones is stimulated by TSH
- CT4 is more active than T3
- DIodine transport in the thyroid follicle is energy dependent
16What happens to protein kinase A (PKA) following the binding of cAMP
- Athe regulatory subunits of PKA dissociate, therby activating the catalytic subunits
- BPKA catalytic subunits bind to the regulatory subunits
- Cthe regulatory subunits dissociate from the catalytic subunits causing inactivation of the enzyme
17Which of the following is NOT TRUE:
- AThyroid hormones T3 and T4 derive from threonine
- BTSH and ACTH bind to cell surface G-proteins coupled receptors (GPCR)
- CInsulin is a polypeptide hormone that consists of A and B chain
- DACTH and endorphins derive from a large precursor called POMC
18Which of the following about testosterone is NOT TRUE:
- ATestosterone is a lipophilic hormone
- BTestosterone has cell surface receptors with tyrosine kinase activity
- CTestosterone is formed from dihydrotestosterone (DHT) in peripheral tissues
- DDHT is formed from testosterone in reaction catalyzed by 5-α-reductase
19Ras protein is a key regulator in cell proliferation and its activity is enhanced by activated tyrosine kinase. Its action include:
- AFormation of c. AMP
- BFormation of c. GMP
- CInitiation of a cascade in which several kinases are activated sequentially by phosphorylation
- DRas is a heterotrimeiric G-protein
20Which of the following is TRUE:
- AAdrenaline and Glucagon inhibit glycogen phosphorylase
- BCortisol stimulates gluconeogenesis and lipolysis
- CAldosterone increases blood pressure
- DThe major driving force for aldosterone biosynthesis is angiotensin II
21Which of the following is TRUE:
- AThe active form of vit. D3 is calcitriol
- BVit. D3 is synthesized in the skin from 7- dehydrocholesterol under UV-light
- CCalcitriol inhibits the intestinal absorption of Ca2+ and phosphate
- DCalcitriol plays important role in bone mineralization
22Which of the following hormones are secreted by the anterior lobe of the pituitary gland?
- AFSH
- BProlactin
- CRenin
- DADH
- EOxytocin
- FTRH
23Insulin:
- Acan signal through MAPK pathway
- Btriggers cAMP- dependent pathway
- Ccan signal through P13K-pathway
- Dhas dimeric receptors with intrinsic tyrosine kinase activity
24Which are the mediators of the signal of lipophilic hormones?
- ACa2+
- BInositol-1,4,5-trisphospahte
- Chormone-receptor complex
- DDAG
25Which of the following statements about thyroid hormones are TRUE?
- AT4 can be a product both of the thyroid and the peripheral tissues
- BT3 can be a product both of the thyroid and the peripheral tissues
- CT3 is more active than T4
- DThyroid receptors are cytosolic intracellular
26Which of the following statements about aldosterone are TRUE?
- Aits synthesis is stimulated by ACTH
- Bits synthesis is stimulated by angiotensin ll
- Cit decreases K+ and H+ excretion
- Dit increases Na+ and water reabsotption
- Eits receptors are cytosolic intracellular
- Fit is synthesized in zona fasciculata of the adrenal cortex
27Which of the following hormones are stored and released by the posterior lobe of the pituitary gland?
- AFSH
- BProlactin
- CACTH
- DADH (vasopressin)
- EOxytocin
28Which of the following statements are TRUE:
- Adivergention of the signal means that different signal pathways have the same common targets or intermediate components
- Bcrosstalk of the signals means that one signal molecule can transmit signals from different extracellular messengers (signal molecules)
- Cacetylcholine transmit its signals through receptors associated with ion channels
- Dacetylcholine transmit its signals through receptors associated with intrinsic serine-threonine kinase activity
29Which of the following hormones have cell-surface receptors?
- Aepinerphrine
- Btestosterone
- Ccalcitriol
- Dinsulin
- Edopamine
- Fretinols
30Based on their mechanism of action the hormones are:
- AAutocrine
- BPeptide
- CSteroid
- DParacrine
- EEndocrine
31Which of the following hormones bind to intracellular receptors:
- AThyroid hormones
- BTSH
- CGlucagon
- DACTH
- ESteroid hormones
32Which of the following hormones have cell surface receptors:
- AGlucagon
- BTestosterone
- CInsulin
- DT4 and T3
- EGrowth hormone
33Which of the following statements about insulin receptor is TRUE
- Ait has intrinsic tyrosine kinase activity
- Bit is located in the nucleus
- Cit is a dimer composed of two α and two β subunits
- Dit is coupled with G-protein
34Which of the following is TRUE:
- AC.AMP is a key second messenger in the transduction of hormone signals
- BAdenylyl cyclase is activated by insulin
- CAdenylyl cyclase catalyzes the synthesis of AMP from ATP
- DHormones like adrenaline, glucagon and ACTH use cGMP as second messenger
35Which of the following is TRUE:
- AInsulin receptor has serine/threonine kinase activity
- BBinding of insulin to its membrane receptor stimulates the tyrosine kinase activity of the β-subunits
- CInsulin is a lipophilic hormone
- DCortisol is a lipophilic hormone
36Which of the following is NOT TRUE:
- ACholesterol side chain cleavage by P450 scc results in production pregnenolone
- BCortisol is produced in zona glomerulosa
- CAldosterone is produced in zona reticularis
- DTestosterone biosynthesis requires aromatase activity
37Which of the following are second messengers:
- AC. AMP
- BInositol- 1,4,5- triphosphate
- CTriacylglycerol
- DDiacylglycerol
- ECa2+ and calmodulin
38Which of the following hormones stimulate adenylyl cyclase:
- AInsulin
- BACTH
- CGrowth hormone
- DTestosterone
- EGlucagon
39Which of the following hormones are cholesterol derivatives:
- ACalcitriol
- BCortisol
- CT3 and T4
- DEstradiol
- EACTH
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- Biochemistry Exam 6- 2nd Year, 2nd Semester- PMU
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