Flashcards
Overview of Immunology
Flashcards do conjunto (20)
- 1physical barriers in innate immunity solidskin
nose hairs
mucous membranes (respiratory & GI) - 2physical barriers in innate immunity liquidtears
saliva
mucus - 3physical barriers in innate immunity moleculesdefensins
lysozyme
stomach acid - 4lysozymefound in tears & mucus
digests bacterial cell walls - 5physiological responses in innate immunitysneezing
coughing
release of soluble factors in inflammatory response - 6soluble factors in inflammatory responsecytokines
kinins
vasoactive amines
defensins - 7cytokinesproteins binding receptor on target cell membrane
alter target cell behavior
alter body temperature (fever)
fatigue & aches
target endothelial cells & cells in blood - 8kininstrigger changes in blood vessels
trigger release of neuropeptides
activate sensory nerves (pain) - 9defensinson skin & mucosal surfaces
tongue & cornea
punch holes in bacterial cell membranes - 10bradykininactivates sensory nerves causing pain
dilates blood vessels causing redness & heat
increases vascular permeability causing swelling/edema - 11complementdirectly kills pathogens
activates & recruits white blood cells
causes tissue cells to release cytokines - 12pro-inflammatory triadIL-1, IL-6, TNF-alpha
systemic inflammatory response - 13extravasationcytokines make white blood cells sticky
white blood cells stick lightly to vessel walls
white blood cells roll along
endothelial cells leak near infection/injury site
white cells move into inflamed area - 14three classes of cytokineschemokines
interleukins (ILs) & interferons (IFNs)
colony stimulating factors (CSFs) - 15chemokinessmall 1k-dalton
conserved cystein patterns per subgroup
stick to endothelial cells making gradient
recruited cells undergo chemotaxis - 16chemotaxismoving along chemokine gradient
- 17ILs & IFNsinterleukins & interferons 10-30 Kd
induce differentiation/proliferation of immature cells
recruit/activate mature effector cells
interferon from infected cells makes neighbors antiviral - 18inflammatory action on hypothalamusreleases prostaglandin
increases body temperature - 19inflammatory action on liverproduction of complement components
upregulates glucose production - 20inflammatory action on bone marrowproduces replacement white cells
if chronic/relapsing, triggers bone resorption and over time, osteoporosis
Informações
- Descrição
- UC Berkeley MCBX110 Week 1
- Criado por
- Ruchira Datta · fev 2021
- Atualizado
- 18 fev 2021
- Visualizações
- 6
- Tags
- Avaliação