PHSI3012 02-2 Limitless replicative potential of cancer cells

Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine about 3 years ago
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PHSI3012 02-2 Limitless replicative potential of cancer cells Content: * Hallmarks of Cancer * Cellular proliferation * Mortality vs immortality * Telomeres * Telomerase * ALT
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Resource summary

Question 1

Question
True or false: Cells which have entered senescence have a large, flattened morphology "like poached eggs".
Answer
  • True
  • False

Question 2

Question
Mutations in p53 and/or Rb can lead to:
Answer
  • Bypassing senescence and crisis.
  • Bypassing senescence and entering crisis.
  • Entering crisis.
  • [none of the above]

Question 3

Question
Cells in "crisis" have which of the following traits? (select all that apply)
Answer
  • Massive cell death
  • Reduced cell death
  • Increased genomic stability
  • Genomic instability

Question 4

Question
The Hayflick limit is:
Answer
  • The number of divisions a cell can undergo before entering senescence.
  • (not this one)

Question 5

Question
Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
Answer
  • 5 - 15
  • 50 - 150
  • 500 - 1,500
  • 5,000 - 15,000
  • 130 - 210
  • 2,000 - 40,000

Question 6

Question
There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT. What does ALT stand for? [blank_start]_____[blank_end]
Answer
  • Alternative Lengthening of Telomeres

Question 7

Question
Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
Answer
  • Germ line cells
  • Stem cells
  • Cardiomyocytes

Question 8

Question
Telomerase is:
Answer
  • An enzyme
  • A protein
  • A molecule

Question 9

Question
Which telomere maintenance mechanism is used in the majority of cancers?
Answer
  • Telomerase
  • ALT

Question 10

Question
Telomerase can be detected using which of the following methods: (select all that apply)
Answer
  • TRAP (Telomere Repeat Amplification Protocol) assay
  • TRF (Terminal Restriction Fragment) assay
  • APBs (ALT-associated PML Bodies)
  • C-circle assay
  • Movement of the telomere tag

Question 11

Question
ALT can be detected using which of the following methods? (select all that apply)
Answer
  • TRAP (Telomere Repeat Amplification Protocol) assay
  • TRF (Terminal Restriction Fragment) assay
  • APBs (ALT-associated PML Bodies)
  • C-circle assay
  • Movement of the telomere tag
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