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PHSI3012 02-2 Limitless replicative potential of cancer cells

Michael Jardine 11 questions

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Questions in this quiz (11)

  1. 1True or false:
    Cells which have entered senescence have a large, flattened morphology "like poached eggs".
    1. ATrue
    2. BFalse
  2. 2Mutations in p53 and/or Rb can lead to:
    1. ABypassing senescence and crisis.
    2. BBypassing senescence and entering crisis.
    3. CEntering crisis.
    4. D[none of the above]
  3. 3Cells in "crisis" have which of the following traits?
    (select all that apply)
    1. AMassive cell death
    2. BReduced cell death
    3. CIncreased genomic stability
    4. DGenomic instability
  4. 4The Hayflick limit is:
    1. AThe number of divisions a cell can undergo before entering senescence.
    2. B(not this one)
  5. 5Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
    1. A5 - 15
    2. B50 - 150
    3. C500 - 1,500
    4. D5,000 - 15,000
    5. E130 - 210
    6. F2,000 - 40,000
  6. 6There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
    What does ALT stand for?
    [blank_start]_____[blank_end]
    1. AAlternative Lengthening of Telomeres
  7. 7Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
    1. AGerm line cells
    2. BStem cells
    3. CCardiomyocytes
  8. 8Telomerase is:
    1. AAn enzyme
    2. BA protein
    3. CA molecule
  9. 9Which telomere maintenance mechanism is used in the majority of cancers?
    1. ATelomerase
    2. BALT
  10. 10Telomerase can be detected using which of the following methods:
    (select all that apply)
    1. ATRAP (Telomere Repeat Amplification Protocol) assay
    2. BTRF (Terminal Restriction Fragment) assay
    3. CAPBs (ALT-associated PML Bodies)
    4. DC-circle assay
    5. EMovement of the telomere tag

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Description
PHSI3012 02-2 Limitless replicative potential of cancer cells Content: * Hallmarks of Cancer * Cellular proliferation * Mortality vs immortality * Telomeres * Telomerase * ALT
Language
English
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