Quiz
Lec 6 - 10
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Questions in this quiz (38)
1Receptors are usually
- Aligands
- Btransmembrane
- CEMM
- Dmessengers
2What is true of receptor based signalling?
- Atarget cells contain the receptor which binds specific signals
- Breceptors can be cytosolic
- Creceptors are stimulated by a hormone or other molecueles
- DAll of the above
3What is true of autocrine/paracrine stimuli?
- Athe signalling cell and the target cell are the same
- Bthe signalling cell and the target cell are different
- Ccarried via blood stream to target cell
- Dboth ligand and receptor are membrane bound on cells in close proximity
4a signal that's carried through the body via the blood stream to target cells throughout the body is
- Aautocrine
- Bendocrine
- Cjuxtocrine
- Dparacrine
5What is false about juxtacrine?
- Ahave shot distance b/w cells
- Bboth ligand and receptor are membrane bound
- Coften for survivial and proliferation
- DB & C
6What happens upon prolactin binding?
- Atwo receptor chains dimerize
- Breceptors bind to ligand
- Ca receptor chain forms a trimer
- DB & C
7What is false about JAK?
- Aphosphorylated the receptor to create docking site
- Bit autophosphrylates
- Cphosphorylates STAT molecules
- Dforms dimers of two receptors
8What is true about the principles of GPCR signalling?
- Athe receptor undergoes a conformational change when activated or deactivated
- BG-protein help activate specific effector molecules
- Cdo not required the association of a G-protein
- DA & B
- EB & C
9G-proteins regulate signal events by
- Aexisting as two interchangeable states of GTP & GDP
- Bbeing held at the plasma membrane by lipid changes that are covalently attached to the alpha and gamma subunits
- CBy hydrolysis
- DA & B
10What is false of the two states of G - proteins?
- AThe active is GTP bound and inactive is GDP bound
- Ban active G-protein becomes inactive by hydrolysis
- Cphosphorylation is needed to interchange b/w the two forms of G- proteins
- DGDP bound can become GTP bound
11What is false about heterotrimeric G - proteins?
- Athey work w GPCR to replay signals
- Bhave 3 diff subunits called beta, alpha, and gamma
- Cthe alpha and beta subunits are linked to lipid chains covalently to hold the G - proteins to the plasma membrane
- DB & C
12What happens when a ligand binds to a receptor in G - protein activation?
- AIt creates a conformational change
- Bdecreases receptor's affinity for G - protein
- CBeta subunit replaced GDP with GTP
- DA & C
13Which subunit creates the nucleotide exchange and of which type, in the G-protein activation stages?
- ABeta. GDP --> GTP
- BBeta, ATP --> ADP
- CGamma, GTP --> GDP
- DAlpha, GDP --> GTP
- EAlpha, GTP --> GDP
14During the G - protein activation, a 2nd messanger is produced. What is it?
- Aeffector
- BcAMP
- CRAF
- DFAK
- EiCAMP
15Which molecules causes the G - protein activation to end signalling?
- AArrestin
- BGRK
- CGlucose
- DCREB
16__________ phosphorylates GPCR and recruits arrestin
- ASARC
- BGRK
- CG alpha subunit
- DGPK
17In glucose modification, heterotrimeric G - protein activates _______________ which catalyzes ________________ from ______________
- Aadenylyl cyclase, cAMP, ATP
- Badenylyl cyclase, Raf, ATP
- CATP, cAMP, GRK
- DArrestin, termination, GRK
18In signal amplification,
- Aa single hormone can activate multiple proteins
- BcAMP an be stoped/destroyed by phosphodiesterase
- CcAMP can only activate PRA
- DA & B
- EA & C
19Which of the following is not a characteristic of 2nd messengers?
- Asome of them are generated from lipids
- BCalcium is an example that can act as a 2nd messenger
- CIt binds to a single receptor
- Dstimulates cellular activity
20What is true about the PH domain?
- Aused by PLC to interact with phophorylated histone rings
- Bcan bind to head group of phospholipid
- Chelps functioning of 1st messenger
- DA & B
21Which of the following does activation of GPCR by acetylcholine not requires?
- Aacetylcholine binding to GPCR to stimulate smooth muscle contraction
- BG-protein to activate PLC which produces only IP3
- CDAG to activate protein kinase- C pathway
- DA & B
22IP3 receptor is
- Aa ligand - gated calcium channel
- Bopening the chanel of IP3 receptors to allow calcium ions into cytoplasm
- Callowing G proteins to hydrolyze
- DA &B
- EAll of the above
23What is the effector protein in the pathway of IP3 production?
- APKA
- Bphospholipase C
- CAdenylyl cyclase
- Ddiacylglycerol
- EPIP2
24What is true regarding receptor tyrosine kinases?
- Athey posses tyrosine kinase activity within a domain of the receptor amino-acid chain
- Ba kinase activity is activated by a second messenger binding to a receptor
- Cno conformational changes occur to activate kinase activty
- Dkinase is activated by phosphrylation
25receptor tyrosine kinases (RTKs) are directly activated by __________ and have _____________
- Aextracellular signals, ligand-binding domain
- Bligand-mediated dimerization, ligand-binding domain
- Cligand-mediated dimerization, extracellular signals
- Dextracellular signals, ligand-mediated dimerization
26which kinase is regulated indirectly by extracellular signals?
- ACytoplasmic protein tyrosine kinase
- BReceptor tyrosine kinase
- CcAMP
- Dligand mediated kinase
27what are the ways receptors can be be brought together?
- Aligand mediated dimerization
- Breceptor mediated dimerization
- Ceffector mediated dimerization
- Dsignal mediated dimerization
- EA & c
- FA & b
- GB & D
28ligand meditated is
- Aone ligand w 2 receptor binding sites
- Beach receptor chain binds one ligand
- Cdimerization is inactive at one point
- DA & C
29What are the functions of autophosphorylation sites on receptor?
- Aregulate kinase activity
- Bfunction as docking sites for signalling molecules
- Cact as activating factors
- DAll of the above
- EA & B
30Which domain binds to phosphorylated tyrosine?
- ASH2 domain
- BSH3 somain
- CPTB domain
31Which domain binds to hydrophobic prolines?
- ASH2
- BSH3
- CPTB
32Which domain binds to phosphotyrosine - binding?
- ASH2
- BSH3
- CPTB
33Which of the following is an adaptor protein?
- AGrb2
- BIRS
- CSTAT
- DSOS
34Which of the following is a docking protein?
- AIRS
- BSTAT
- CSOS
- DShp2
35RAS is a small monomeric G- protein. Which of the following is false?
- ASOS is a GAP for the Ras
- BGEF modulates the activity of it
- Cuses GAP and GDI
- DMutation is the Ras keeps it in off position
36What does GAP do?
- Astiulates hydrolysis of bound GTP to GDP
- Bdecreases duration of signal
- Cinhibits release of bound GTP
- DAll of the above
- EA & B
37What is RAS?
- ASmall GTPase held at the inner surface of the membrane
- BMutation in RAS allows GTP hydrolysis
- CExchanges GDP to GTP
- DInhibits the release of GDP
38Phosphorylated tyrosines form docking sites on active receptors. Identify a protein domain that binds phosphorylated tyrosines
- APTB
- BSH2
- CSH3
- DPH
- EA & B
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- Biology (BIO 331) Quiz on Lec 6 - 10, created by Malaika Abid on 05/04/2018.
- Author
- Malaika Abid
- Language
- English
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