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Pharm II Exam II
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Questions in this quiz (102)
1Which of the following is NOT a general mechanism utilized to treat epilepsy?
- AGABA receptor antagonist activity
- BInhibiting calcium channels
- CActivating potassium channels
- DBlocking sodium channels
2How does antagonizing glutamate receptors help in treating epilepsy?
- AGlutamate is an inhibitory neurotransmitter and therefore inhibiting its receptor can inhibit neurotransmission
- BGlutamate is an excitatory neurotransmitter and therefore inhibiting its receptor can inhibit neurotransmission
- CInhibiting Glutamate channels cause an excitatory response
- DInhibiting Glutamate channels causes a positive membrane potential
3Which of the following is NOT a side effect of benzodiazepines?
- ACardiovascular effects in healthy patients receiving dose causing hypnosis
- BAnterograde amnesia
- CDelirium (mostly in ICU sedation)
- DSlight depression of alveolar ventilation
4Which of the following is correct regarding Z compounds?
- AThey are more specific for sedation
- BThey have more side effects than benzodiazepines
- CThey are more effective as anticonvulsants than benzodiazepines
- DThey have more potential for abuse
5Choose the broad spectrum AED
- APhenytoin
- BLamotrigine
- CLevetiracetam
- DTopiramate
- EValproic acid
- FOxcarbezepine
6Benzodiazepines can be used for long-term use as an anticonvulsant
- ATrue
- BFalse
7Which of the following is the safest to use during pregnancy?
- ATopiramate
- BPhenobarbital
- CValproic acid
- DLevetiracetam
8Which of the following drugs are preferred for status epilepticus?
- ADiazepam
- BLorazapam
- CPhenobarbital
- DClobazam
9Diazepam can be given IM
- ATrue
- BFalse
10Which of the followings is NOT a side effect of phenytoin?
- AMegaloblastic anemia
- BElevated liver enzymes
- CSteven-Johnsons syndrome
- DRare aplastic anemia
11Which of the following is NOT a side effect of carbamezapine
- AHyponatremia
- BIdiosyncratic blood dyscrasias
- CSedation
- DSuicidality
12Which of the following is NOT a side effect of eslicarbazepine acetate?
- AHyponatremia
- BVomiting
- CEosinophilia
- DRenal calculi
13Which of the following is NOT a side effect of Lamotrigine?
- ADecreased plasma levels with use of valproic acid
- BDecreased plasma levels with use of phenobarbital
- CStevens-Johnson syndrome at high doses
- DDecreased half-life with use of phenytoin
14Which of the following is NOT a side effect of lacosamide?
- AEuphoria
- BDiplopia
- CDizziness
- DSkin rash
15Zonisamide can cause renal calculi
- ATrue
- BFalse
16Which of the following can cause suicidality?
- AZonisamide
- BRufinamide
- CLevetiracetam
- DVigabatrin
17Which of the following causes behavioral changes and extrapyramidal reactions?
- ALamotrigine
- BEthosuximide
- CVigabatrin
- DRufinamide
18Which of the following can cause significant cognitive impairment?
- APhenobarbital
- BPhenytoin
- CLamotrigine
- DFelbamate
19Which of the following has an effect on though processes and level of consciousness?
- AVigabatrin
- BTiagabine
- CBenzodiazepines
- DCarbamezapine
20Which of the following AED causes retinal dysfunction?
- AVigabatrin
- BTiagabine
- CGabapentin
- DPregabalin
21Keppra has more milder CNS effects than Gabapentin.
- ATrue
- BFalse
22Which of the following drugs has a risk of causing GI effects and liver toxicity in patients younger than two years old?
- ATopomax
- BValproic Acid
- CPhenytoin
- DPhenobarbital
23Which of the following drugs has an important adverse effect that is similar to that of Zonisamide, along with dose-related cognitive effects?
- AValproic acid
- BTopomax
- CPhenobarbital
- DCarbamazepine
24Which of the following drugs has a side effect of aplastic anemia and acute hepatic failure and therefore is rarely used?
- APeramanel
- BFelbamate
- CTopomax
- DEthosuximide
25Which of the following has risk of causing neuropsychiatric events such as aggression, anger, irritability, agitation, and mental status changes?
- APerampanel
- BFelbamate
- CPregabalin
- DEzogabine
26Which of the following is NOT true regarding Ramelteon?
- AIt is a non-benzodiazepine hypnotic
- BIt is selective for MT1 and MT2 receptors
- CHas has higher risk for addiction
- DIt is less efficacious than benzodiazepines as a hypnotic
27Which of the following is a characteristic of tolerance?
- AExposure to a drug induces changes that result in decrease of the drug's effects over time
- BManifests by a specific withdrawal syndrome
- CCompulsive use
- DProduced by abrupt cessation
28Which of the following could give a patient, who is allergic to sulfa drugs, a reaction?
- AZonisamide
- BEzogabine
- CTigabatrin
- DGabapentin
29Which of the following is NOT true regarding dexmedetomidine?
- AIt is a nonBZD hypnotic
- BIt is a selective alpha2 receptor agonist with sedative properties
- CIt causes tachycardia and hypertension
- DUsed in ICU setting
30What is the difference between dalfampridine and Dimethyl Fumarate when treating MS?
- ADalfampridine is a DMT and Dimethyl Fufurate is for symptom management
- BDalfampridine is for symptom management and Dimethyl Fufurate is a DMT
- CDalfampridine is an anti-inflammatory and Dimethyl Fufurate is a DMT
- DThere is no difference
31Which of the following does NOT cause cognitive effects?
- APrimidone
- BPhenobarbital
- CTopomax
- DValproic acid
32Which of the following is NOT excreted renally/ requires adjustment in patients with renal dysfunction?
- AGabapentin/Pregabalin
- BLevetiracetam
- CValproic acid
- DTopiramate
33Which of the following does NOT have a GI side effect?
- AEthosuximide
- BValproic acid
- CPerampanel
- DLacosomide
34Ethosuximide and Perampanel have behavioral side effects
- ATrue
- BFalse
35Which of the following mechanisms is correct for amphetamines?
- ASelectively inhibits the reuptake of NE
- BThey are taken up into the cell and interfere with vesicular monoamine transporter, depleting stores and stimulating release of these NT
- CSelectively inhibit reuptake of DA
- DMechanism is unknown
36What is the clinical use for amphetamines?
- AADHD
- BNarcolepsy
- CObesity
- DAll of the above
37Which of the following is NOT a side effect of amphetamines?
- AIncrease suicidal ideation
- BDecrease fatigue
- CAnorexia
- DIncrease blood pressure
38Methohexital can cause the following EXCEPT
- AHypotension
- BPorphyria
- CRespiratory depression
- DBronchospams
39Which of the following is a side effect of propofol?
- AIncreased cerebral metabolic rate
- BHypertension
- CAnti-emetic action
- DAll of the above
40Which of the following is a side effect of Etomidate?
- AElectrolyte imbalance
- BHypertension
- CTachycardia
- DAnti-emetic activity
41Which of the following is NOT a side effect of Ketamine?
- ACataleptic state
- BPost-op disorientation
- CAnalgesic properties
- DDecrease in cerebral blood flow
42Drugs such as Benztropine, Oxybutynin, Antivert, and Tolterodine add synergistic effects to oral CheI
- ATrue
- BFalse
43Which of the following best describes the mechanism of oral ChEI?
- AThey inhibit the reuptake of Ach
- BThey block ChE, preventing further breakdown of Ach
- CBlock reuptake of DA
- DNone of the above
44ChEI are used for symptomatic improvements of dementia, not slow the progression of the disease
- ATrue
- BFalse
45ChEI are used for moderate to severe dementia
- ATrue
- BFalse
46Which of the following is NOT a side effect of ChEI?
- AGI
- BTachycardia
- CUrinary obstruction
- DAsthma
47Which of the following is NOT true regarding Memantine?
- APrevents futher neurodegeneration caused by excitotoxic reactions by blocking NMDA receptors
- BUsed for moderate to severe Alzheimers
- CMay need dose adjustment in older patients due to renal excretion
- DGI is the most common side effect
48Which of the following statements is FALSE?
- AChEI, such as Neostigmine and Pyridostimine, can be used as reversal agents for non-depolarizing neuromuscular blockers
- BSuccinylcholine requires a reversal agent due to its onset of action
- CNaltrexone can reverse the effects of opioids
- DNone of the above
49Which of the following is NOT true regarding ethanol?
- AIt enhances GABA-mediated inhibition and blocks NMDA receptors
- B90-95% is metabolized in the liver into acetic acid
- CCan cause euphoric effects a low-moderate doses
- DAcute effects, such as increased risk for cancer occurs
50Which of the following is NOT used for treatment of ethanol toxicity?
- ADisulfram, to inhibit aldehyde dehydrogenase
- BNaltrexone, which acts as opiate antagonist to produce positive effects in alcohol
- CAcamprosate, which acts as a weak glutamate antagonist
- DFomepizole, a competitive inhibitor of alcohol dehydrogenase
51Which of the following is NOT used as treatment for methanol toxicity?
- AEthanol, since it has a higher affinity for alcohol dehydrogenase
- BFomepizole, a competitive inhibitor of alcohol dehydrogenase
- CBenzodiazepines, for withdrawal symptoms
- DAlkalinization with sodium bicarbonate to avoid metabolic acidosis
52Which of the following is NOT a side effect of use of fomepizole in treatment of methanol toxicity?
- AAgitation
- BDizziness
- CEosinophilia
- DRetinal and optic-nerve damage
53Which of the following is NOT a side effect of use of ethanol to treat methanol toxicity?
- APancreatitis
- BHypoglycemia
- CMental status change
- DEosinophilia
54Which of the following is NOT true regarding Atomoxetine (Strattera)
- AEffects are not apparent until 2 weeks
- BUsed as 1st line therapy
- CUsed to treat ADHD
- DCan be used in patients who have a h/o illicit substance abuse or concerns about abuse
55Which of the following is a side effect of atomoxetine (Strattera)
- ASuicidal ideation
- BIncreased appetite
- CHypotension
- DHeadache
56Which of the following is true regarding malignant hyperthermia?
- ACaused by increase release of Ca2+ from the sarcoplasmic reticulum
- BWorsens with use of Dantrolene
- CTreated with Desflurane
- DDoes not have a genetic disposition
57Which of the following is true regarding Chantix?
- AIt is a nicotine-based therapy
- BIt is a partial agonist and antagonist, to cause partial stimulation and suppress withdrawal
- CIt is started the same day patient quits smoking
- DMore effective as monotherapy than in combination with other nicotine0based therapies
58Which of the following is NOT a side effect of Chantix?
- ANausea
- BSuicidal ideation
- CCardiovascular events in patients with cardiovascular disease
- DPhysical dependence
59Which of the following is NOT possible side effect of Pancurinium?
- AAtrophy
- BMyalgia
- CIncrease in HR/BP
- DAccumulation of laudanosine
60Choose the Antispasm centrally-acting muscle relaxants
- ADiazepam
- BBaclofen
- CTizanidine
- DCarisoprodol (SOMA)
- EChlorzoxazone
- FCyclobenzaprine
- GMetaxalone
- HMethocarbamol
- IOrphenadrine
- JDantrolene
61Choose ALL of the following Antispasm drugs that have anticholinergic side effects
- ACarisoprodol
- BChlorzoxazone
- CCyclobenzaprine
- DMetaxalone
- EMethocarbaol
- FOrphenadrine
62Which of the following is true in regards to Levodopa and its use?
- AIt can cross the BBB, which is not true about DA
- BShould be taken with food
- CNo development of tolerance
- DThese are all true
63Which of the following extrapyramidal symptoms is NOT reversible?
- ATardive dyskinesia
- BDystonias
- CParkinson-like symptoms
- DAkathisia
64Which of the following is NOT used for management of EPS?
- AAnticholinergic drugs
- BAntihistamine with anticholinergic activity
- CTrihexyphenidyl
- DAll are used for management
65Which of the following is an anticholinergic side effect?
- ABradycardia
- BWakefulness
- CSalivation
- DUrinary retention
66Atypical antipsychotics have anticholinergic side effects
- ATrue
- BFalse
67Which of the following is a side effect of TCA?
- AOrthostatic hypotension
- BBradycardia
- CWakefulness
- DDiarrhea
68Which of the following is NOT true regarding Antipsychotics and their side effects?
- AAtypical agents cause weight gain more, except for aripirazole.
- BTypical agents cause more prolactin elevation and EPS/TD, except paliperidone and risperidone (Atypical agents)
- CQTc prolongation is seen with the use of chlorpromazine (typical AP)
- DRisk of sedation, Anticholinergic side effects, and Orthostatic Hypotension is low with aripiprazole (atypical AP)
69Atypical antipsychotics cause less TD
- ATrue
- BFalse
70Which of the following is NOT a side effect of Parkinson's drugs
- AOrthostatic hypotension
- BHallucinations
- CDyskinesia
- DAnxiety
71Which of the following is the correct reasoning for giving Carbidopa with Levodopa?
- ATo inhibit the conversion of Levodopa into DA in the periphery, thus allowing levodopa to cross the BBB
- BSo that carbidopa crosses the BBB and prevents breakdown in the CNS
- CInhibit MAO-B to prevent breakdown of DA
- DTo inhibit COMT and thus prevent breakdown of DA
72Which of the following is correct regarding the On-Off phenomenon?
- AIt occurs at the very first administration of levodopa
- B"On" periods occur as levodopa levels decline
- C"Off" periods occur shortly after bolus of Levodopa is given
- DDescribed as fluctuations of rigidity and normal/dyskinetic movements
73Which of the following is a side effect of lithium?
- AGI distress
- BHypothyroidism
- CRenal failure
- DAll are side effects of lithium
74Rasagiline forms toxic metabolites, whereas Selegiline does not
- ATrue
- BFalse
75Choose ALL of the following that cause weight gain
- ASNRI
- BSSRI
- CWellbutrin
- DTCA
- EMirtazepine
- FVortioxetine
- GMAOIs
- HLevomilnacipram
76Which of the following is a side effect of serotonin agonists?
- ADecrease in blood pressure
- BCoronary vasospasm
- CConstipation
- DDiscontinuation syndrome
77Which of the following is a side effect of serotonin antagonists?
- ASexual dysfunction
- BSerotonin syndrome
- CSuicidal ideation
- DQT interval prolongation
78Which of the following is true regarding Vilazodone?
- AShould be avoided with food
- BHas antagonistic activity at the 5-HT3 receptor
- CIt is a partial agonist at 5-HT1A receptor, which speeds up the onset of action and possibly augments the anxiolytic effects
- DSuperior to other antidepressants
79Which of the following is true regarding Vortioxetine?
- AEfficacy is seen at higher doses
- BHas an advantage over other antidepressants
- CIt has anti-emetic effects due to antagonistic activity at the 5-HT3 receptor
- DIt causes weight gain
80Parkinson's drugs typically cause hallucinations
- ATrue
- BFalse
81Which of the following causes psychosis?
- AMAOI
- BOpioids
- CAnticholinergics
- DThese all cause psychosis
82Which of the following is a difference between SSRIs and SNRIs?
- ASSRIs cause weight gain, whereas SNRIs can cause decrease in appetite
- BSSRIs cause increase in blood pressure and heart rate
- CSNRIs cause urinary retention
- DSNRIs cause dose-related GI symptoms that resolve after 2 weeks
83Which of the following does NOT cause serotonin syndrome?
- ASerotonin antagonists
- BSSRIs
- CVilazodone
- DDextromethorphan
84Which of the following best describes serotonin syndrome?
- AFluctuations in motor function with periods of stiffness/rigidity and periods of normal or dyskinetic movements
- BIt occurs when there is an overdose with a single drug, or concurrent use of several drugs that results in excess serotonergic activity
- CIncludes side effects such as dizziness, nausea, weakness, HA, anxiety, irritability, and insomnia
- DIncludes side effects such as hypothermia, hypotension, bradycardia, and dyskinesia
85Which of the following drugs inhibits reuptake of 5-HT and NE?
- AEscitalopram
- BDesipramine
- CLevodopa
- DSumatriptan
86Which of the following drugs inhibits reuptake of ONLY 5-HT?
- ANortriptyline
- BDuloxetine
- CParoxetine
- DSelegiline
87Which of the following drugs is used to treat migraine by stimulating 5-HT1D receptors, causing cranial vasoconstriction?
- AOndansetron
- BSertraline
- CAlmotriptan
- DThese are all 5-HT1d stimulants
88Which of the following drugs acts as an anti-emetic by antagonizing 5-HT3 receptors?
- AVortioxetine
- BVilazodone
- CPalonosetron
- DDuloxetine
89Which of the following drugs is a partial agonist at 5-HT1A receptor, which speeds up the onset of action and possibly augments the anxiolytic effects?
- AVilazodone
- BVortioxetine
- CParoxetine
- DTrazodone
90Which of the following drugs has 5-HT1A agonistic activity and 5-HT3 antagonistic activity?
- AVortioxetine
- BParoxetine
- CFluoxetine
- DGranisetron
91Typical antipsychotics, such as Chlorpromazine, are more potent in inhibiting 5-HT2 receptors than D2 receptors
- ATrue
- BFalse
92Atypical antipsychotics, such as Clozapine, are more potent in inhibiting 5-HT2 receptors than D2 receptors
- ATrue
- BFalse
93Which of the following drugs is NOT used to inhibit the breakdown of L-DOPA or DA?
- ACarbidopa
- BSelegiline
- CTolcapone
- DLevommilnacipran
94Which of the following drugs is NOT an SNRI?
- AVenlafaxine
- BMilnacipran
- CDuloxetine
- DFluoxetine
95Which of the following drugs is NOT an SSRI?
- ASertraline
- BCitalopram
- CParoxetine
- DVortioxetine
96Which of the following does NOT have anticholinergic side effects?
- ATCA
- BDiphenydramine
- CBenztropine
- DAlosetron
97Which of the following is more commonly seen with typical antipsychotics?
- AQTc prolongation
- BEPS/TD
- CWeight gain
- DSedation
98Which of the following is NOT typically seen with use of atypical antiopsychotics (except for paliperidone and risperidone)
- AWeight gain
- BProlactin elevation
- CSedation
- DOrthostatic hypotension
99Clozapine is seen to having the following effects, except for
- ASedation
- BAnticholinergic effects
- COrthostatic hypotension
- DProlactin elevation
100Which of the following classes of antidepressants can cause suicidal ideation?
- ASSRI-like antidepressants
- BSSRI
- CSNRI
- DTrazadone
101Which of the following antidepressants causes increase in blood pressure and heart rate?
- ATCA
- BSsRI
- CSSRI-related
- DSNRI
102Which of the following antidepressants does NOT cause discontinuation syndrome?
- ASSRI
- BSSRI-related
- CSNRI
- DTCA
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- CNS
- Author
- Diana Flores
- Language
- English
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