Neuro Pharmacology - Depression and Anxiety

Description

KUSOP Pharmacology III "Sample Questions"
Ifeoma Okekearu
Quiz by Ifeoma Okekearu, updated more than 1 year ago
Ifeoma Okekearu
Created by Ifeoma Okekearu over 8 years ago
48
3

Resource summary

Question 1

Question
Activation of the thalamus can activate the innate fear pathway. Without the collaboration of the prefrontal cortex, this activation can lead to fear manifestations without a source.
Answer
  • True
  • False

Question 2

Question
Which of the following statements about the manifestation of anxiety/fear symptoms is not true?
Answer
  • Lesions of the medical prefrontal cortex increases the risk for anxiety.
  • Inhibition of the orbitofrontal cortex leads to the hyperactivity of the amygdala in the presence of a potential threat which produces fear responses.
  • In the innate fear response, the thalamus is activated by the amygdala with sequential prefrontal cortex activation leading to the fear manifestation.
  • The amygdala mediates key functions in the processing of fear and threat-related information.

Question 3

Question
Select all of the options that are effective in the treatment of anxiety disorder
Answer
  • Relaxation Training
  • Systematic Desensitization
  • Group Therapy
  • Pharmacotherapy

Question 4

Question
Select the statements about the tuberomamillary nucleus that are true
Answer
  • It is inhibited by GABA from the ventrolateral pre optic area.
  • It is activated by glutamate
  • It is inhibited by orexin
  • Histamine promotes calm wakefulness through H2 receptors

Question 5

Question
Where to benzodiazepines bind and what is their mechanism of action?
Answer
  • They bind to a niche between the α and γ subunits of the GABAa receptors behaving as GABA agonist
  • They bing to the niche between the α and γ subunits of the GABAb receptors acting as a positive allosteric modulator
  • They bind to a niche between the α and γ subunits of the GABAa receptors behaving as positive allosteric modulators
  • They bing to the niche between the α and γ subunits of the GABAb receptors acting as a GABA agonist

Question 6

Question
Positive modulation of the GABAa receptors of the amygdala will produce a hypnotic effect
Answer
  • True
  • False

Question 7

Question
Flumenazil is a GABA antaagonist
Answer
  • True
  • False

Question 8

Question
Which anti-xiolitic(s) would be a good choice for an elderly patient?
Answer
  • Lorazepam
  • Temazepam
  • Diazepam
  • Chlordiazepoxide

Question 9

Question
Drugs binding to α1, α2, α3, α5, and γ subunits of the GABAa synaptic receptor mediate phasic inhibition triggered by peak concentrations of GABA predisposing users to dependence.
Answer
  • True
  • False

Question 10

Question
What is the recommended rate of reduction for people wanting to discontinue the use of benzodiazepines?
Answer
  • Stop immediately and drink a lot of water
  • Flumenazil injections over the course of 5-7 days
  • Decrease by 10 percent each day
  • None of the above responses are correct

Question 11

Question
Barbiturates produce an anti-xiolitic effect by binding to the β subunit of the GABA-a receptor. At high concentrations, they can mimic GABA and directly activate chloride channels.
Answer
  • True
  • False

Question 12

Question
Overdose of barbiturates can lead to death due to respiratory and cardiac depression and the lack of an effective antagonist.
Answer
  • True
  • False

Question 13

Question
Monoamine Oxidase Inhibitors are Indicated for use with Barbiturates because they shorten the length of action, decreasing side effects.
Answer
  • True
  • False

Question 14

Question
What statement below is accurate regarding the changes the amounts of BDNF in the brain of depressed patients?
Answer
  • There is an INCREASE in the amount of BDNF in the Hippocampus and a DECREASE in the amount of BDNF in the Nucleus Accumbens
  • There is an INCREASE in the amount of BDNF in BOTH the Hippocampus and the Nucleus Accumbens.
  • There is a DECREASE in the amount of BDNF in BOTH the Hippocampus and the Nucleus Accumbens.
  • There is a DECREASE in the amount of BDNF in the Hippocampus and an INCREASE in the amount of BDNF in the Nucleus Accumbens.

Question 15

Question
Which class of anti-depressants cause the "Cheese Effect"
Answer
  • MAOIs
  • SSRIs
  • NMDA Blockers
  • SNRIs
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