Quiz
Leukaemia
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Questions in this quiz (40)
1Define leukamia
- ANeoplastic proliferation of haemopeoietic or lymphoid cells
- BNeoplastic proliferation of lymphoid cells
- CNeoplastic proliferation of bone marrow
2In acute leukaemia, abnormality occurs in mature cells
- ATrue
- BFalse
3Acute leukaemia is described as a block in differentiation
- ATrue
- BFalse
4Acute leukaemia is caused by acute proliferation of...
- AMyeloblasts
- BLymphoblasts
- CBoth (rare)
- DBoth (most common)
5What are the symptoms of chronic leukaemia?
- ANo block in differentiation
- BBlock in differentiation
- CLow proliferation
- DHigh proliferation
6Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
- ABlasts
- BReticulocytes
- CLympocytes
7In A.L, there are often reticulocytes in the peripheral blood
- ATrue
- BFalse
8Leukaemia is caused by clonal proliferation from a single cell
- ATrue
- BFalse
9How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
- AMyeloblasts have auer rods
- BLymphoblasts have auer rods
- CMyeloblasts have a large, pale nucleus
- DLymphoblasts have a large, pale nucleus
10MUD stands for
- AMatched Unrelated Donor
- BMyeloblast Unknown Death
- CMyeloblasts Under Duress
11Remission - no disease in the blood
- ATrue
- BFalse
12Why use the Minimal Residual Disease (MUD)?
- AAssess chances at relapse/need for further treatment
- BAssess effectiveness of drug
- CPrevent remission
13BMT - Bone Marrow Transplant
- ATrue
- BFalse
14B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
- ATrue
- BFalse
15Which of the following is has the poorer prognosis
- AAcute T-Cell Precursor Lymphoblastic
- BAcute B-Cell Precursor Lymphoblastic
16What is found in cytogenetic testing of ALL?
- AHyperploidy
- BAneuploidy
- CNullosomy
17Which of the following are found in ALL cytochemistry?
- AMPX/SB are neg
- BMPX/SB are pos
- CPAS block pos
- DPAS block neg
18Which of the following are found in Immunophenotyping for ALL?
- ACD19
- BCD7
- CCD10
19What is true of AML?
- AInc WBC
- BDec RBC
- CDec Plateles
- DInc RBC
- EInc Platelets
20AML means there is no normal cells
- ATrue
- BFalse
21What markers are used in Flow Cytometry to identify AML?
- ACD13
- BCD33
- CCD12
- DCD4
22AML is more common in adult women
- ATrue
- BFalse
23When is AML called 'De Novo'
- AWhen it occurs for the first time
- BIf it occurs secondary to other malignancies
- CIf it never relapses
24Which of the following is common in AML (as opposed to ALL)
- ACNS leukaemia
- BLymph, spleen and gum problems
- CLymphodenopathy
25Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC- AA2, B3, C1
- BA1, B2, C3
- CA3 B2 C1
26CML- accumulation of mature myeloid cells
- ATrue
- BFalse
27Genetic anomalies in CML occur low down where they effect cells
- ATrue
- BFalse
28What happens in 95% of cases to cause AML?
- AChromosome 22 shortens
- BLinking BCR & ABL genes together
- CChromosome 22 inverts
- DChromosome 22 lengthens
29In indentifying CML, immunophenotyping is useless
- ATrue
- BFalse
30CML is more common in adult men
- ATrue
- BFalse
31What is the WBC in CML?
- A>50 x 10^9/l
- B<30 x 10^9/l
- C>75 x 10^9/l
32What will be found in a CML bone marrow sample?
- ABone marrow is hypercellular
- BBone marrow is hypocellular
- CMyeloid cells are present at all developmental stages
- DInc Neutraphil Alkaline Phosphatase
- ERed Neutraphil Alkaline Phosphatase
33Glivec stops CML cells dividing, but is expensive
- ATrue
- BFalse
34CLL- Neoplastic proliferation of mature looking lymphocytes
- ATrue
- BFalse
35What ususally happens in CML?
- ALymphoids form masses in the bone marrow, spleen and lymph nodes
- BLymphoids lyse and release contents as they are made poorly
- CLymphs begin attacking body cells
36In CLL, the lymph population can be over 300x the normal
- ATrue
- BFalse
37What are smear cells?
- ACells that rupture during a smear
- BCells so malleable they look like smudges
- CCells so deformed they form masses, which look like smears
38In CLL, the bone marrow is <25% lymphocytes
- ATrue
- BFalse
39What does immunophenotyping in CLL tell us?
- AClonality
- BWhich lymph cells they are
- CThe markers
40CLL is more common in old men
- ATrue
- BFalse
Information
- Description
- Haematology and Anatomy (Leukocytes) Quiz on Leukaemia, created by gina_evans0312 on 09/01/2014.
- Author
- gina_evans0312
- Language
- English
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- 527
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