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Tox: Rodenticides

dhardis1 9 questions

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Questions in this quiz (9)

  1. 1Which of the following is an INCORRECT matching of rodenticide to their mode of action?
    1. ACholecalciferol: incr serum Ca by incr intestinal absorption of Ca, stimulating osteoclastic bone resorption, incr renal re-absorption from distal tubules of kidney -> metastatic mineralization of tissues
    2. BZinc phosphide: gas produced and absorbed through the GIT (corrosive agent)-> oxidative phosphorylation by blocking CytC -> reactive oxygen sp -> peroxidation in tissues with high o2 demand (heart/brain/kidney/liver)
    3. CBromethalin: competitive antagonist of glycine in spinal cord and medulla -> decr Cl channel in motor neurons -> excess sensory input and neuronal activity
    4. DBrodifacourin: inhibits vit K epoxide reductase (which is necessary for vit K regeneration and recycling to active form) -> decr in clotting factor formation and depletion of currently circulating clotting factors (2, 7, 9, 10)
  2. 2Which is INCORRECT with regards to anti-coagulant rodenticides?
    1. AWarfarin is less toxic to domestic species than the second generation anti-coagulant rodenticides when ingested
    2. BThe second generation anti-coagulants undergo enterohepatic circulation, thus are more toxic to the liver
    3. CThese rodenticides may target predator species (i.e. birds of prey) whom ingest the infected, deceased prey species
    4. DSecond generation anti-coagulant rodenticides are more toxic to cats than dogs (cats have a lower LD50 in mg/kg)
    5. EIf you suspect an exposure to an anti-coagulant rodenticide, 3 hours after client's history of an ingestion, treat with emesis and activated charcoal
  3. 3An owner brings you both of her dogs. One is convulsing presently and appears to be paralyzed when not convulsing. The other dog appears fine except for a little ataxia in the rear legs. You decide to keep both dogs at the clinic and treat the convulsing one symptomatically. Approx 6 hours later, the ataxic pup is paralyzed in the rear legs, depressed, has mm tremors, but is still not convulsing. Which of the following is true concerning this toxicity case?
    1. AThe prognosis for both dogs if treated is very very bad. They're gonna die
    2. BYou would expect to smell a fishy, garlicy odor if you smelled their breath
    3. Cthe poison you suspect is meant to target pigeons and starlings
    4. Dthe 2nd dog, with the delayed onset of hind leg paralysis has a better prognosis than the other dog if treated with emesis and repeated dosing of activated charcoal
  4. 4Lets talk about strychnine. Select all that are TRUE.
    1. ADO NOT use diazepam to control seizures it will exacerbate the seizing
    2. BAny manipulation/contact with the animal may result in extreme rigidity and respiratory compromise
    3. CBest way to diagnose in the live animal is by testing the stomach contents or urine
    4. DClinical signs include violent tonic seizures, "grinning appearance" with ears drawn together over the head, nervousness, excessive salivation, saw-horse stance, hyperesthesia
    5. EClincal signs include blue/green/red feces from the rodenticide dye, vomiting, dyspnea/coughing, petechiae/ecchymosis, frank hemorrhage, shock, coma, cavital bleeding
  5. 5Metaldehyde, a molluscicide, can cause hyperthermia
    1. ATrue
    2. BFalse
  6. 6Keep your psoriasis cream under lock and key bc if your dog eats it, it could cause opacified kidneys
    1. ATrue
    2. BFalse
  7. 7Which is INCORRECT with regards to medical treatment for neurotoxicity?
    1. Aoptimal administration of benzodiazepines to control seizures and tremors is INTRAVENOUS
    2. Bmethocarbomol is used to treat muscle tremors
    3. Ctry to take any blood samples prior to drug administration
    4. Dpentobarbital is lipophilic and is rapidly distributed to all tissues, highest concentrations in brain and liver
    5. Epropofol has less cardiovascular depression than pentobarbital at doses required for treatment of seizures
    6. Fall of the options are CORRECT
  8. 8Nightshade (Solanum malaxylon) can cause coagulopathies because they inhibit Vit K1 epoxide reductase when ingested as do warfarin rodenticides.
    1. ATrue
    2. BFalse
  9. 9Strychnine is used in humans as a laxative, an appetite stimulant, and a "street drug"
    1. ATrue
    2. BFalse

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Description
(Toxicology) Quiz on Tox: Rodenticides, created by dhardis1 on 24/04/2014.
Author
dhardis1
Language
English
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toxicology
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