Pituitary adenoma

Seite 1

Pituitary adenoma

> 1 cm

For a prolactin secreting pituiary adenoma

Increase in prolactin --> oestrogen, stress --> dopamine --> prolactin --> breast --> lactation

Decrease in growth hormone

Decrease in ACTH --> CRH --> ACTH --> adrenal cortex --> cortisol, androgen --> stress

Decrease in cortisol --> ADH --> distal nephron --> water balance

Decrease in FSH

Decrease in LH

Decrease in testerone --> GnRH --> LH and FSH --> gonads and ovaries --> oestrogen, progesterone, androgen --> reproduction

Decrease in ultra sensitive TSH --> TRH --> TSH --> thyroid --> T4, T3

Decrease in free T4

Decrease in insulin like growth factor --> IGF-1 --> GHRH, somatostatin --> GH --> Liver --> IGF-1, IGF-BP3 --> growth

Seite 2

Two lobes of pituitary

Anterior pituitary: synthesis and secretes hormones --> LH, FSH, TSH, PL, GH, ACTH

Posterior pituitary: ADH, oxytocin