Control of Insulin Secretion

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Control of Insulin Secretion

Insulin is secreted by the B-cells in the Islets of Langerhans of the pancreas

Normally the cell membrane is polarised, because of the sodium potassium pumps

When blood glucose is high, B-cells absorb more glucose, respire more and produce more ATP

The ATP closes the potassium channels, so the membrane charge changes

Na+ is actively pumped out; K+ can diffuse out. Inside is relatively negative

Calcium channels open, and the calcium initiates the movement of insulin conataining vesicles to the membrane... exocytosis occurs

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