451716
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
Describe the structure of Sec61
Antworten
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Trimeric- Alpha, beta and gamma subunits
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Dimeric- 1A & 1B subunits
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Tetrameric- A, B, C & D subunits
Frage 2
Frage
What of the role of Sec 61 in ER transport?
Antworten
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Forms the pore itself
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Binds the nascent polypeptide
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Folds the nascent polypeptide once it's passed through
Frage 3
Frage
Which pore-associated protein interacts with the signal recognition particle?
Antworten
-
SR-alpha
-
SR-beta
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SR-gamma
Frage 4
Frage
What is the role of the Sec62/63 complex?
Antworten
-
Contains a J domain
-
Contains a G/F domain
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That signals the ATPase domain of Hsp40 in the ER (Bip)
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That signals the ATPase domain of Hsp70 in the ER (Bip)
Frage 5
Frage
The Bip protein acts as a ratchet, pulling the protein through and preventing it moving backwards
Antworten
- True
- False
Frage 6
Frage
The first Asparagine to enter the ER has what added to it?
Antworten
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Mannose
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Acetyl-N Glucosamine
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Acetyl-N Galactosamine
-
Moiety
Frage 7
Frage
The sugar added to the Asparagine is 12 residues long
Antworten
- True
- False
Frage 8
Frage
Once the sugar has been added, what happens?
Antworten
-
Glucosidase 1 & 2 remove glucose residues
-
Fructosidase 1 & 2 remove fructose residues
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Galactosidase 1 & 2 remove galactose residues
Frage 9
Frage
Once the residues have been removed, the protein is folded by one of which chaperones?
Antworten
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Calnexin
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Calreticulin
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Cal-Chaperonin
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Calregulin
Frage 10
Frage
The Cal_ protein doing the folding will be bound to Erp57
Antworten
- True
- False
Frage 11
Frage
What happens after the protein has been folded?
Antworten
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Another glucose is removed
-
Another fructose is removed
-
Another galactose is removed
Frage 12
Frage
Once the final residue is removed, the protein enters ERAD quality control, in which 2 things can happen
Antworten
- True
- False
Frage 13
Frage
Other than exiting the ER as a correctly folded protein, what can happen after protein folding is complete?
Antworten
-
Protein is reglycosylated
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Protein has mannose residues removed
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Protein has ions added
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Protein is degraded
Frage 14
Frage
In the case of a misfolding that the ER can correct, what protein is used to signal this?
Antworten
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Glycoprotein Glycosyl Transferase
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Mannosidase I
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EDM's
Frage 15
Frage
What proteins remove mannose resiudes of proteins to be degraded?
Antworten
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Glucosidase
-
Glycoprotein Glycosyl Transferase
-
Mannosidase
-
EDM's
Frage 16
Frage
Which protein leads a misfolded protein out of the ER to be degraded in the protesome?
Antworten
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Hrd1-E3
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Glycoprotein Glycosyl Transferase
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Sec53
-
YDJ1
Frage 17
Frage
What is the role of Epr-57?
Antworten
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To make/break disulphide bonds
-
To cleave Signal Recognition Particle
-
To bind Calreticulin to the membrane
Frage 18
Frage
Calnexin is membrane bound, Calreticulin is not
Antworten
- True
- False
Frage 19
Frage
In Cal_ and Cal_, where on the protein to be folded to they bind?
Antworten
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Lectin domain- an exposed glucose residue
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Pectin domain- an exposed Fructose residue
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Plectrin domain- an exposed mannose residue
Frage 20
Frage
The protein end not bound to the sugar residue binding site is bound to what?
Antworten
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The membrane
-
Erp-57
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SSa
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