451983
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Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
Physical modifications are reversible
Antworten
- True
- False
Frage 2
Frage
Give an example of protein oxidation
Antworten
-
Disulphide bond formation
-
Hydrogen bond formation
-
Glycosylation
Frage 3
Frage
Where are proteins with oxidated modifications are nearly universally found where?
Antworten
-
Outside the cell
-
The cytoplasm
-
Nucleus
-
I.e. Oxidative environments
Frage 4
Frage
What is so useful about disulphide bonds?
Antworten
-
They're heat stable
-
They're protease resitant
-
They're structurally resilient
Frage 5
Frage
Where do oxidation reactions occur?
Antworten
-
The golgi
-
The ER
-
The ribosome
Frage 6
Frage
Disulphide bonds assist in recovery from denaturation
Antworten
- True
- False
Frage 7
Frage
In Maristoylation, what is added?
Antworten
-
Maristic acid
-
Maristoylate
-
Maristoyl-3-phosphate
Frage 8
Frage
Describe the substrate added in Myristoylation
Antworten
-
4C
-
5C
-
6C
-
Saturated & hydrophobic
-
Unsaturated & hydrophilic
Frage 9
Frage
What is the point of Myristoylation?
Antworten
-
It polarises a protein
-
It binds a protein to a membrane
-
It binds two ends of a protein together
Frage 10
Frage
What sequence is the Myristoylation substrated added to?
Antworten
-
The N-terminus
-
The C-terminus
-
MGXXX(T/S)
-
MPXXX(G/F)
-
SDXXX(S/R)
Frage 11
Frage
The protein that performs Myristoylation is N-Myristoyl transferase
Antworten
- True
- False
Frage 12
Frage
How is the Myristoylation substrate added?
Antworten
-
First the phenylalinine is removed
-
First the methionine is removed
-
First the tyrosine is removed
-
Then the substrate is added to the glycine
-
Then the substrate is added to the leucine
-
Then the substrate is added to the isoleucine
Frage 13
Frage
Prenylation is the addition of ketones
Antworten
- True
- False
Frage 14
Frage
Name the two substrates most often added in prenylation
Antworten
-
Farnesyl
-
Geranylgeranyl
-
Derisyl
-
Nitrosyl
Frage 15
Frage
Where does prenylation occur?
Antworten
-
In a CAAX box (where A should be Alanine, but anything small and hydrophobic will do)
-
In a FAAX box (where A should be Isoleucine, but anything small and hydrophobic will do)
-
In a CAAT box (where A should be Alanine, but anything small and hydrophobic will do)
Frage 16
Frage
In prenylation, the X of the sequence must be the terminal aa of the chain
Antworten
- True
- False
Frage 17
Frage
Put the following in order
A- The COOH group is modified to a methyl group to make it uncharged
B- The substrate is added to the cystine
C- The last three aa are removed
Antworten
-
A-C-B
-
B-C-A
-
A-B-C
Frage 18
Frage
Prenylation is done to proteins destined for the cytoplasm
Antworten
- True
- False
Frage 19
Frage
Name the types of glycosylation
Antworten
-
N-linked
-
O-linked
-
C-Mannosylation
-
Phosphoserine Linked
Frage 20
Frage
Glycosylation is the addition of carbohydrate chains
Antworten
- True
- False
Frage 21
Frage
What is the site of N-linked glycosylation?
Antworten
-
The Asn in an NX(S/T)
-
The Phe in an FX(S/T)
-
The Gly in a GX(S/T)
Frage 22
Frage
What is the residue that is attached to the amino acid?
Antworten
-
Mannose
-
Glucose
-
N-acetyl-galactosamine
-
N-acetyl glucosamine
Frage 23
Frage
What residues are on the tips of the branches?
Antworten
-
Mannose
-
Glucose
-
Fructose
Frage 24
Frage
If the branches end with mannose, what is the process called?
Antworten
-
High-mannose Biantennary N-glycosylation
-
High-mannose N-glycosylation
-
Mannosylation
Frage 25
Frage
Why are 3 glucose added to the sugar complex in the golgi?
Antworten
-
So they can be removed as markers for protein folding and transport
-
So the Golgi knows they're bound for the membrane
-
So the Golgi can degrade the protein as faulty
Frage 26
Frage
Why is it called High-Mannose Biantennary N-Glycosylation?
Antworten
-
Because one of the three branches is removed, giving two 'antenna'
-
Because another branch is formed off the first one, giving two 'antenna'
-
Because proteins with this type of glycosylation act as receptor proteins with two antenna
Frage 27
Frage
Once the Biantennary complex has been formed, what happens next?
Antworten
-
Mannose is removed
-
Addition of N-acetyl neuraminic acids
-
Addition of glucose
-
Removal of N-acetyl glucosamine
-
Addition of a fucose to the GlcNac bound to the amino acid
Frage 28
Frage
Why the complicated process of adding and removing sugars?
Antworten
-
It adds a date stamp to the cell- over time the NeuAc's fall off, which signals the protein for degredation
-
It adds a transport signal- depending on what is added or removed, proteins are directed to different areas by carrier proteins
-
It's quality control- the contortions required to add and remove all the sugars mean that the protein has folded properly
Frage 29
Frage
The HIV virus can use glycosylation to hide from the immune system
Antworten
- True
- False
Frage 30
Frage
Why is N-linked glycosylation potentially dangerous?
Antworten
-
Because the immune system is programmed to ignore it, viral coat proteins can use it to hide the virus
-
Because NeuAc's can be toxic in high concentrations
-
Because the removal of mannose can cause the protein to misfold
Frage 31
Frage
HIV1-gp120 has many N-X-(T/S) sequences to be glycosylated
Antworten
- True
- False
Frage 32
Frage
Where does HIV1-gp120 bind?
Antworten
-
CD4 receptor
-
CD8 receptor
-
B-lymphocyte receptors
Frage 33
Frage
How does the HIV virus invade the lyphocyte?
Antworten
-
It's only glycosylated on a very small binding site
-
It's only not glycosylated on a very small binding site
-
Which allows it to bind and invade
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