473842
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
The vascular endothelium protects platelets from subendothelial aggregating substances i.e. collagen
Antworten
- True
- False
Frage 2
Frage
Vasoconstriction around injured site helps coagulation how?
Antworten
-
Reduced blood flow decreases pressure and loss of blood
-
Reduced blood flow brings coagulation factors into tissue contact more readily
-
Reduced blood flow decreases wall diameter, decreasing size of breach
Frage 3
Frage
Why is Fibrinolysis necessary?
Antworten
-
It prevents inappropriate extension of the fibrin plug
-
Prevents clotting from damaging nearby cell
-
Prevents clotting in case of infected blood
Frage 4
Frage
To prevent inappropriate prevention of coagulation, where are coagulation inhibitors limited to?
Antworten
-
Intact endothelium
-
Breached endothelium
-
Free flowing blood
Frage 5
Frage
Inhibitors are triggered by late products of coagulation
Antworten
- True
- False
Frage 6
Frage
What is inhibited by the Tissue Factor Pathway Inhibitor?
Antworten
-
FX reversibly
-
FX permanently
-
FVII
-
FV
Frage 7
Frage
Anthithrombin deactivates several enzymes of the coagulation system
Antworten
- True
- False
Frage 8
Frage
Protein S & C work the same way
Antworten
- True
- False
Frage 9
Frage
The Protein C pathway is initiated by what?
Antworten
-
Thrombin
-
Antithrombomodulin
-
Antithrombin
Frage 10
Frage
Thrombomodulin works in the free flowing blood
Antworten
- True
- False
Frage 11
Frage
Both thrombin and thrombomodulin work on the endothelial cell surface
Antworten
- True
- False
Frage 12
Frage
What is the role of thrombomodulin?
Antworten
-
Conversion of Thrombin to Antithrombin
-
Conversion of Thrombin to a Coagulation Inhibitor
-
Removal of platelets
Frage 13
Frage
Excess thrombin binds to thrombomodulin on intact cells, which allows it to be altered
Antworten
- True
- False
Frage 14
Frage
Protein C acts as an anticoagulant by degrading Factors
Antworten
-
V
-
VIII
Frage 15
Frage
Protein C needs Mg in order to function
Antworten
- True
- False
Frage 16
Frage
Which of the following support Protein C activity?
Antworten
-
Protein S
-
Inactive F V
-
Active F V
Frage 17
Frage
60% of patients with thrombophilia have a
Antworten
-
Factor II deficiency
-
Protein C deficiency
-
Protein S deficiency
Frage 18
Frage
VTE = Venous Thromboembolism
Antworten
- True
- False
Frage 19
Frage
What is thrombosis?
Antworten
-
An increased liklihood of spontaneous clotting
-
An inability to form blood clots
Frage 20
Frage
Name the risk factors for thrombophilia
Antworten
-
Alteration in blood components i.e. pregnancy
-
Circulatory stasis i.e. venous problems
-
Artificial surfaces i.e. a STENT
Frage 21
Frage
VTE occurs when blood coagulation overwhelms fibrogenlysis/anticoagulant mechanisms
Antworten
- True
- False
Frage 22
Frage
Thrombophilia is linked to Lupus Anticoagulant Syndrome
Antworten
- True
- False
Frage 23
Frage
Name some examples where Anticoagulation therapy is necessarry
Antworten
-
Patient with a myocardial infarction (MI)
-
Patients with Lupus/APS
-
Deep Vein Thrombosis/ Primary Embolism
Frage 24
Frage
How is Heparin administered?
Antworten
-
Intravenously
-
Subcutaneously
-
Ingestion
Frage 25
Frage
How does Heparin work?
Antworten
-
Increases action of Antithrombin
-
Increases Protein C activity
-
Increases degredation of platelets
Frage 26
Frage
Why is Low Molecular Weight Heparin better?
Antworten
-
100% bioavalibility
-
Longer half life
-
Less frequent osteoporosis
Frage 27
Frage
Dabigatran is only used in cases of Atrial Fibrilation
Antworten
- True
- False
Frage 28
Frage
Dabigatran is a FX inhibitor, Rivaroxabin is a thrombin inhibitor
Antworten
- True
- False
Frage 29
Frage
Warfarin works how?
Antworten
-
Directly inhibits thrombin
-
Inhibits Vit K metabolism
-
Lyses platelets
Frage 30
Frage
Without Vitamin K, why is coagulation so much slower?
Antworten
-
Non carboxylated factors cannot bind to Ca2+
-
Non carboxylated factors cannot bind to phosphorylated
-
Non carboxylated factors cannot be inhibited
Frage 31
Frage
Warfarin is used when all four clotting factors are low
Antworten
- True
- False
Frage 32
Frage
What is the leading dose of Warfarin?
Antworten
-
6mg for 3 days
-
3mg for 6 days
Frage 33
Frage
What test is used to monitor warfarin activity?
Antworten
-
Prethrombin time
-
Activated Partial Thromboplastin Time
-
Fibrin Assay
Frage 34
Frage
What is the reference for Prethrombin Time?
Antworten
-
Standard reference thromboplastin
-
Potency is ISI- International Sensitivity Index
-
Standard reference antithrombin
Frage 35
Frage
INR = Prethrombin Time/ Mean Normal Prethrombin Time
Antworten
- True
- False
Frage 36
Frage
Match the dangerous INR ranges-
A= (2-3)
B= (3-4)
Antworten
-
A= Prosthetic Heart Valves B = DVT
-
A = DVT B = Prosthetic Heart Valves
Frage 37
Frage
When using Warfarin, stop if the INR <2 for two consecutive days
Antworten
- True
- False
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