Cells 2: Blood and Blood Cells - Types of Anaemia

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- Using lecture & ABS notes
HaEun Ji
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Anaemia Low blood haemoglobin concentration
Microcytic Small MCV
Microcytic Failure of haemoglobin synthesis (hence smaller erthrocytes)
Microcytic Caused by iron deficiency as a result of gradual blood loss e.g. menstruation, GIT lesions or cancers and parasitic infection
Normocytic Normal MCV
Normocytic Red blood cell production is normal, but is a result of acute blood loss.
Macrocytic Large MCV
Macrocytic Failure in DNA synthesis and cell division (during erythropoeisis). Folic acid (thymine synthesis) and Vit B12 are essential for division.
Macrocytic Vit B12 deficiency: pernicious (gradual but harmful) anaemia Folic acid deficiency: pregnancy
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