Quiz
Immunology Block 2
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Questions in this quiz (21)
1All of the following are part of Fab region of Ig except?
- AVH
- BVL
- CCH 2
- DCL
2VH and VL determines the idiotype and CH2 and CH3 determine the isotype of Ig
- ATrue
- BFalse
3Antigen Binding site
- ASpecificity is determined by hypervariable regions within the variable domain
- BEach variable region has 3 hypervariable regions called complementary determining regions (CDRs)
- CAn antigen binding site is composed of 3 light chain CDRs and 3 heavy chain CDRs
- DAll of the above are true
- ENone of the above
4Ig Determinants
- AIsotypic : constant domain, present in all individuals of a species
- BAllotypic: constant domain; different alleles within a species
- CIdotypic: antigen binding site
- Dall of the above are true
- E1&2 are true
5Antibodies interact with molecules by the Fc receptors (constant region)
- ATrue
- BFalse
6Regarding different classes of Ig a
- AIgG - Monomer - circulating - Most abundant in serum - crosses transplacentally via brambell receptor
- BIgM - Pentamer - Surface of B cells or circulating - Ag receptor on B cell - First class of Ab released by B cells during primary response
- CIgA - Monomer - Surface of B cells - Important for B cell activation - Co-expressed with IgM on B cells due to differential RNA splicing
- DIgD - circulating monomer, secreted dimer - circulating in plasma or secreted in saliva ,tears, milk etc - protects mucosal surfaces
- EIgE - Monomer - circulating or cell bound - found in mast cells and basophils - High affinity IgE receptors binds in the absence of Ag
- FAll are correct
- G1,2,5 are correct
- H3,4 are correct
- IAll are wrong
7Regarding Pro-B cell all are true except?
- ANo Ig is expressed
- BRecombination Signal Sequences (RSS) & 12/23 rule regulate arrangement & ensure that proper joining occurs: D-J --> V-DJ
- CRAG1/RAG2 recognised and binds to Il-7R
- DPalindromic nucleotide addition at hairpin loop formation by DNA polymerase
- ENon-template nucleotide addition at hairpin loop formation by TdT
8Regarding Pre-B cell
- AIgM expressed
- BAllelic Exclusion: RAG1/RAG2 is repressed to stop VDJ rearrangement of H locus
- CRAG1/RAG2 is re-expressed for VJ rearrangement - Somatic Recombination - of each daughter cell's L chain
- DKappa light chain recombines 1st
- Eall of the above are correct
9Immature B cell - all are true except
- AIgG expressed
- BNegative Selection for Tolerance - Immature B cell with no self reaction will continue on to maturity and leave the bone marrow
- CLight chain rearranges for a chance to make BCR with new specificity
- DImmature B cell binds multivalent self-antigen and fails receptor editing --> Clonal deletion (apoptosis)
- Emmature B cells bind soluble self-antigen --> Clonal anergy
10Mature B cell express IgM + IgD due to differential RNA splicing
- ATrue
- BFalse
11CD21 co-receptor binds Fc of Ig (ITIM) - positive co-receptor --> activation
FcyR binds to C3d - negative co-receptor --> no activation- ATrue
- BFalse
12Following is the sequence of events 1st T_B cell interaction - all of the following are true except?
- AAntigen activated B cell (APC) migrates toward T-B boundary and present antigen by MHC II to CD4+ Helper T cell
- BCD40 activates T Helper to express CD40-L and cytokines
- CCD40-CD40-L bind and T Helper releases cytokines toward B cell
- DMutated CD40-L results in X-Linked agammaglobulinemia
- EProliferation of activated B cell to form germinal centers (Clonal expansion)
- FAID (Activation Induced Deaminase) inserts point mutations in the variable regions of BCR for diversification of BCR
13All of the following regarding 2nd T-B cell interaction are true except?
- AClass/Isotypic Switching : The constant region of the heavy chain undergoes change of Ig Isotype but the selected variable region stays the same maintaining antigenic specificity and affinity
- BIsotype is determined by cytokines released from Helper T cell
- CEnables the same assembled Vh exon to be associated with different CH genes in the course of an immune response thus increasing the divrsity of Ig function
- DIl-4 secreting T cell stimulate Plasma cell production and Il-10 secreting T cell stimulate memory B cell production
14Thymus independent response the antigens are polysaccharides and the antibody made is always IgM because there is no class switching, no affinity maturation and no memory cell formation
- ATrue
- BFalse
15MHC Class I is expressed on the surface of all nucleated cells including RBC
- ATrue
- BFalse
16Endogenous pathway MHC I and Exogenous pathway MHC II
- ATrue
- BFalse
17Antign processing is proteolytic deradation of proteins into peptides of a suitable size for binding to MHC
Antigen Presentation - actual display of the processed peptide bound to MHC molecules on the surgace of an APC or target cell- ATrue
- BFalse
18T cell recognize non linear and conformational determinants
- ATrue
- BFalse
19Dendritic cells are exception to the rule - Cross presentation allows exogenous proteins to be presented on MHC I and endogenous proteins to be presented by MHC II by autophagy
- ATrue
- BFalse
20Viral proteins interfere with MHC I
- AInhibit peptide transport
- BInhibit peptide loading
- CCause MHC I degradation
- Dall of the above
- Enone of the above
21Intracellular bacteria evade MHC II by
- AEscape endosomes
- BNeutralize endosome acidification
- CBlock fusion with lysosomes
- DSequesters MHC II molecules after vesicle fusion
- EAll of the above
Information
- Description
- Review on B cells
- Author
- ivenkat
- Language
- English
- Views
- 28
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