Flashcards
Histopathology intro
Cards in this deck (10)
- 1Histopathology changes of tissuesModified - deranged or infiltrated by inflammation
Growth - degenerative by necrosis or proliferative by hyperplasia
Foreign by bacteria or fungi - 2Observable acute inflammation signs (hrs - 14 dayz max)- Rubor due to altered blood flow
- tumor masked by tissue shrinkage
Good indicator of disease - 3AI characterisationsVasodilation
Increased vascular permeability
Margination and Emigration
Many neutrophils - 4Degenerative changes of AI - pyknosis - karyorrhexis - karyolysis- Nuclear shrinkage
- nuclear degradation
- nuclear fading - 5Reactive changes of AIActive tissue repair, cellular proliferation, mitosis, growing capillaries
- 6outcomes of AIRecovery – tissue returns to normal
Healing – tissue returns to healthy state but usually with scarring
Progression to chronic inflammation - 7chronic inflammation (CI) czusesPersistent infections
Non-degradable materials
Autoimmune disease - 8CI macrophages e.g. epithelioid and Langhan's giant cells jobsTissue destruction by active macrophages induces repair mechanisms
Tissue shows signs of healing – large numbers of active fibroblasts, new collagen formation and angiogenesis – can lead to fibrosis - 9Healing of CIRecovery – No tissue loss. Minor damage – tissue returns to normal.
Regeneration – tissue loss, but replaced with new tissue that is same as original.
Repair – scar tissue. - 10repair depends on tissue typesLabile tissue – epithelial
Stable tissues - normally non-mitotic but can become mitotic if there is damage or loss (e.g. liver may regenerate….up to a point).
Permanent tissues – Repaired tissue lacks full functionality.
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- BIOL 282 - Cellular pathology Flashcards on Histopathology intro, created by Jumael Zafar on 12/11/2019.
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- Jumael Zafar
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