Flashcards
Genotoxicity
Cards in this deck (7)
- 1Define a genotoxicantAnything with the capacity to damage DNA
- 2How are damage and mutation linked?Damage may initiate repair which may lead to misrepair, leading to mutation
- 3What type of cell may be affected?Germ Cell - Offspring Damage
Somatic Cell - Self Damage - 4What are the most commonly attacked sites but genotoxic agents?Guanine and adenine bases
- 5What are the different types of DNA damage?DNA adducts
Methylation/alkylation
Oxidated bases
Depurination - 6Outline methylationCommonly occurs to cytosine.
Methylation occurs, where a CH3 is added to the cytosine ring. Then a deamination occurs and the NH2 is removed and replaced by an O.
This ultimately leads to the formation of Thymidine, which changes the base pairing and hence can change the expression of the DNA - 7Outline Oxidises basesOH or O groups are added covalently to bases, which ultimately changes the pairing
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- Flashcards on Genotoxicity, created by ajanxi on 24/04/2015.
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