592690
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 12 years ago
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| Question | Answer |
| Resevoir | A human case or carrier |
| Transmission | Through contaminated food (can incubate for 7-14 days) |
| Symptoms | Fever (20% mortalility) and complications- ulcers, meningitis |
| Adherence to cells | Type III Secretory system |
| Macrophage Invasion | Used to enter lymph, where it can enter the blood |
| Primary Bacteraemia | Where s.typhi enter the blood to infect other organs (i.e. the Gall Bladder) |
| Secondary Bacteremia | Where bacteria leave the organs they have colonies to enter the blood again |
| Cause of Symptoms | Secondary Bacteremia |
| Cause of Carrier | Bacteria have colonise the gall bladder but no symptoms are produced |
| Salmonella Pathogenicity Island | Allows s.typhi to avoid Toll Like Receptors |
| V.I | Capsule protein that protects it from TLR4 |
| TV.I | Inhibits flagelling expression, that protects from TLR5 |
| S. typhi Resistance in the Gall Bladder | Can bind to gall stones, forming a biofilm and preventing antibiotic removal |
| Intracellular Multiplication | Hides in the gall bladder epithelium and multiplies |
| Treatment | Antibiotics (and possible gall bladder removal) |
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