Flashcards
Thyroid Pharm
Cards in this deck (14)
- 1DRUGS USED TO TREAT HYPOTHYROIDISM?THYROID HORMONES/ SYNTHETIC THYROXINE
1) Levothyroxine
- synthetic T4
2) Liothyronine
- synthetic T4
3) Liotrix
- synthetic T4 & T3 - 2NORMAL THYROID HORMONE FUNCTIONSIncrease metabolic rate, protein synthesis, cardiac output, renal perfusion, oxygen use, body temperature, blood volume, and growth processes.
- 3LEVOTHYROXINE ( Use & MOAFor: HYPOthyroidism
Thyroid hormone replacement therapy
MOA: most is converted to T3 in body. Thus can produce nearly normal levels of both T3 & T4 - 4LEVOTHYROXINE AE & MonitoringAE: can cause cardiac stimulation
Monitor: T4 & TSH levels
s/s of hypo/hyperthyroidism
* when taken correctly rarely causes AE - 5LEVOTHYROXINE Drug Interactions & Nursing ConsiderationsnNarrow therapeutic index,
Long half life (~7days)
- b/c highly protein bound
- slow to "kick in", ~ 1mo to reach steady state
Drug-Drug Interactions:
many can reduce absorption and accelerate metabolism - 6WHAT TREATS HYPERTHYROIDISM?ANTI-THYROID DRUGS= THIONIMIDES
1) Propylthiouracil
2) Methimazole - 7PROPYLTHIOURICAL Uses & MOAFor: Graves disease & HYPERthyroidism
MOA: suppress/block synthesis of thyroid hormones.
Interferes with Iodine incorporation AND can inhibit peripheral DE-iodination of T4 to T3 - 8PROPYLTHIOURACIL AE & Nursing ConsiderationsAE: Liver injury, agranulocytosis, rash
NC: safer ( than methimazole) for use in women who are pregnant or breastfeeding ; doesn’t cross the placenta easily b/c protein bound - 9METHIMAZOLE Uses & MOAFor: Graves disease & HYPERthyroidism
MOA: suppress/block synthesis of thyroid hormones.
Interferes with Iodine incorporation - 10METHIMAZOLE AE & Nursing ConsiderationsAE: Agranulocytosis= increased risk of infection
Neonatal hypothyroidism in pregnancy
*Not rec in pregnancy- breast milk and transplacental passage. - 11WHAT ARE 2 COMMON E IODIDE PRODUCTS ?1) Lugols Solution
Strong iodine solution of 5% elemental iodine and 10% potassium iodide
5-8 drops Q6hr
2) Saturated Solution of Potassium Iodide (SSKI)
6 drops Q6hr - 12POTASSIUM IODID Uses & MOAFor: Acute treatment of HYPERthyroidism
MOA: creates such high levels of iodide that it will:
- reduce iodine uptake by thyroid gland
- inhibit thyroid hormone production
- block release of thyroid hormones into bloodstream - 13POTASSIUM IODIDIE AE & PrecautionsAE: Iodism= brassy taste in mouth, burning sensation in mouth, sore teeth.
Precautions: use of potassium-sparing diuretics, potassium supplements, and ACE inhibitors increases the risk of hyperkalemia.
-intake of foods high in iodine - 14EVALUATION OF DESIRED EFFECTS- Decreased T4 levels
- Reduction in size of thyroid gland
- improved sleep, weight gain; blood pressure and heart rate w/in range
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- Graduate NURSING PHARMACOLOGY (Nursing Pharmacology) Flashcards on Thyroid Pharm, created by Kate Parvey on 15/07/2017.
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- Kate Parvey
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